Barrett's oesophagus

Question 1

Pathophysiology of Barrett’s oesophagus

Answer 1

Stratified squamous epithelium metaplasia to simple columnar epithelium with goblet cells, due to reflux oesophagitis

Question 2

Symptoms of Barrett’s oesophagus

5

Answer 2

1. Reflux
2. Dysphagia
3. Haematemesis
4. Weight loss
5. Chest pain

Question 3

Investigation for Barrett’s oesophagus

Answer 3

1. Endoscopy with biopsy

Question 4

Management of Barrett’s oesophagus

Answer 4

1. Low-grade: annual endoscopy
2. High-grade: endoscopic resection, radiofrequency ablation
3. Adenocarcinoma: surgery

Question 5

What percentage of patients with Barrett’s develop adenocarcinoma every year?

Answer 5

0.5%