bacterial survival mechanisms Flashcards
What does TCP facilitate
Facilitates adhesion of pathogen to target site on host
How does vibrio cholerae begin its infection inside the body
Penetrates gut mucosal barrier and starts production of TCP (toxin-có regulated pilus) and CT (cholerae toxin) via ToxR regulon
What is ToxR regulon in vibrio cholerae
Regulatory system controls expression of genes for bacterium’s virulence
What is ToxR regulon involved in the production of
Cholera toxin CT and toxin-coregulated pilus TCP
What are three pathogensis patterns
Adhesion and entry
Epithelial barrier breach
Toxin production
What is the process of adhesion and entry of the pathogensis pattern
Epithelial barrier destabilisation and fluid secretion causes severe intestinal inflammation and diarrhoea
What is the process of epithelial barrier breach in the pathogensis patterns
Adhesion and entry to epithelium causes epithelial genotoxic stress response
What is the process of toxin production in pathogensis patterns
Intercellular spread and immune evasion causes epithelial destruction + prevention of immunological memory
What is the T3SS
Type 3 secretion system
What are common themes in pathogensis
-breach of epithelial barrier
-proliferation intraphagosomally
-toxin release and delivery
-immune evasion
-effector release via T3SS
What are secretory systems
Intra and inter cellular communication v important for export of nutrients and protection against host-mediated response
What are two common secretion machenaries
Sec and TAT
What are the properties of sec and TAT
Transport proteins across cytoplasmic membrane
Gram-negative transport proteins also use specialised secretion systems
How does the sec system transport proteins
Transports proteins in unfolded state
What are the 3 components of the sec protein
Protein targeting component - SecB
Motor protein - SecA
Conducting channel - SecYEG
