B&B: Herpes Viruses

Question 1

All Herpes viruses are

Answer 1

enveloped
ds DNA
linear
Icosahedral
Large
Take envelope from nucleus itself (not cell membrane)

Question 2

4 Herpes viruses lead to giant cell formation

Answer 2

HSV1
HSV2
VZV
CMV
Visible in Tzanck Smear

Question 3

HSV-1

Answer 3

Oral herpes, Herpetic Whitlow, Keratoconjunctivitus, Encephalitis (temporal lobes)

Question 4

HSV-2

Answer 4

Oral herpes, genital herpes, meningitis

Latent in lumbar-sacral ganglia

Question 5

HSV-1, HSV-2, VZV Tx

Answer 5

acyclovir
valacyclovir
famciclovir

Question 6

HSV-2 Tx

Answer 6

Supressive with acyclovir

Question 7

HSV-1, HSV-2, VZV histo

Answer 7

Intranuclear inclusions

Cowdry A inclusions

Question 8

EBV causes mono by infecting

Answer 8

B cells

Question 9

EBV

Answer 9

Envelope glycoprotein gp350/220 binds B-cell receptor CD 21
CD21 is receptor for C3d fragment of complement
CD21 is also called C3d receptor, EBV receptor and CR2

Question 10

EBV mono histo

Answer 10

Atypical lymphocyte: CD8+ T cells

Question 11

CMV histo

Answer 11

Owl’s Eye nuclei

Question 12

CMV can be latent in

Answer 12

monocytes/marrow cells

Question 13

CMV Tx

Answer 13

Ganciclovir, Foscarnet, Cidofovir

Question 14

Congenital CMV Tx

Answer 14

TORCH infection
Ganciclovir
Valganciclovir

Question 15

HHV-6 causes

Answer 15

roseola infantum (sixth disease)

Question 16

HHV-6

Answer 16

Starts with febrile phase

Then fever breaks and maculopapular rash that starts in neck and trunk, spreads to face and limbs

Question 17

HHV-6 Tx

Answer 17

Self-limiting: No Tx

Question 18

HHV-8 causes

Answer 18

Kaposi’s Sarcoma