B-3 Infection and response Flashcards

1
Q

What is a pathogen

A
  • Pathogen is a microorganism that can cause infection disease
  • may be bacteria, virus, protists or fungi
  • Can be seen in plants or animals.
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2
Q

What are the characteristic of viruses and bacteria

A
  • Bacteria- very small cells- reproduce rapidly- may produce toxins that damage cells and produce toxins
  • Virus- not cells- tiny- reproduce rapidly inside body live inside cells and replicate- spread- cell damage makes you feel ill- burst and release new virus
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3
Q

What are the characteristics of Fungi and protists

A
  • Protists- All eukaryotes- most single celled- some parasites- live on or inside organisms and cause damage
  • Often carrie day vector who does not get disease
  • Fungi- Single celled or body made fro hyphae- grow and penetrate human skin and surface and skin causing disease
  • Can produce spores which spread to other plants and animals
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4
Q
  • How can pathogens spread
A
  • Water- Drinking or bathing- e.g cholera.
  • Air- carried in air and breathed in- cough or sneeze e.g influenza virus
  • Direct contact- Touching- e.g skin. E.g athletes foot
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5
Q
  • What is measles
A
  • Viral disease showing symptoms of fever and red skin
  • Serious can be fatal with complications
  • Spread through inhalation of droplets from infected persons sneezes of coughs
  • Children are vaccinated against it
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6
Q
  • What is HIV
A
  • Initially causes flu like symptoms - can feel no symptoms for years after
  • Unless controlled with antiretroviral drugs it can attack immune system
  • Can cause AIDS when boys immune system becomes so weak it cannot cope with infection or cares
  • Spread by sexual contact or exchange of bodily fluids- e.g needles
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7
Q

What is Tobacco mosaic virus

A
  • Plant pathogen affecting many species of plants including tomatoes
  • Causes mosiac pattern - discolouration
  • Lack of photosynthesis - lac of growth
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8
Q

What is Rose black spot

A
  • A fungal disease where purple or black spots develop on the leave- often turn yellow and drop
  • Photosynthesise reduced- growth-
  • Spread in water or wind
  • Treated using fungicides and removing affected leaves
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9
Q

What is malaria

A
  • Pathogens cause malaria are protists
  • Life cycle that includes mosquito
  • Causes episodes of fever- can be maya;
  • Prevent vectors from breeding and using mosquito nets
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10
Q

What is salmonella

A
  • Food poisoning spread by bacteria - secrete toxins
  • Fever, stomach cramps, vomiting and diarrhoea
  • Uk most poultry vaccinated- limits spread
  • Contaminated eating
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11
Q
  • WHAT IS GONORRHOEA
A
  • STI-
  • Thick yellow discharge and pain when urinating
  • caused by bacteria
  • Used to be easily treated with penicillin- became resistant
  • Barrier method anti antibiotics
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12
Q

What can be done to reduce the risk of the spread of disease

A
  • Being hygienic- stop you infecting
  • Destroying vectors- protists cannot be transferred
  • Isolating infected individuals- stops spreading
  • Vaccination- Can’t get it
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13
Q

What is the non-specific defence system

A
  • Skin- Barrier- antimicrobial substance- kill pathogens
  • Hairs and mucus- trap practices that contain pathogens
  • Trachea and bronchi- Cilla- waft mucus that contains pathogens back up
  • Stomach- hydrochloric acid- kill
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14
Q

What are phagocytes

A
  • White blood cells
  • Engulf and digest
  • Foreign cells
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15
Q

What role do white blood cells have on your immune system,

A
  • Travel around and attack and destroy pathogens
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16
Q

What are lymphocytes- Antibodies

A
  • Every pathogen has unique antigens on surface
  • When white blood cells come across foreign antigen they produce antibodies-
  • These antibodies lock on so they can be found and destroyed by other white blood cells- try new antigens - will only lockout that one
  • Antibodies produced rapidly and carried to do to all cells
  • Stored as memory lymphocytes so if they come back again can be destroyed quickly
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17
Q

What are antitoxins

A

-Toxins produce by the living bacteria

18
Q

What does vaccination involve

A
  • Introducing small amounts of dead or inactive forms of pathogens into body
  • Stimulates white blood cells to produce antibodies
  • If the same disease comes back the memory lymphocyte will know the antibody needed
19
Q

How does vaccination prevent illness on a population level

A
  • If large proportion of population is immune the spread is very limited
  • Disease may even disappear
  • Herd immunity
  • Can re-appear
  • Whopping cough- 1980s- safety concerns- substantial number does
20
Q
  • What are the pros and cons of vaccines
A

Pros-

  • Helped control lots of disease e.g polio, whooping cough, mumps
  • Eradicated small pocks and 95% of polio now gone
  • Large outbreaks and be prevented if vaccinated

Cons

  • DOn’t always work
  • Can get a bad reaction- rare
21
Q

What are antibiotics

A
  • Medicines that help cure bacterial disease by killing infective bacteria inside body.
  • Specific bacteria treated by specific antibiotic
22
Q

What uses to antibiotics and other medicine have in treating disease

A
  • -Actually kill or prevent growth the bacteria without killing body cells
  • Different for each bacteria
  • Cannot kill viruses
23
Q

What is the issue with finding drugs for viruses

A
  • Viruses reproduce using body own cells which makes it difficult to kill them with killing your own body
24
Q

What has the use of antibiotics done

A
  • Greatly reduced the number of deaths from communicable disease caused by bacteria
25
Q
  • `what are the steps in bacteria becoming resistant to antibiotics
A
  • Bacteria can mutate-become resistant
  • If have infection some bacteria may be resistant to antibiotics
  • Only the non-resistant strain survives
  • This then reproduces and increase in number-
  • Could cause serious infection that antibiotics can treat

e.g MRSA caused wound infections and is resistant to methicillin

26
Q

What can be done to stop down the rate at which resistant strains develop

A
  • Doctors can stop overprescribing

- Finish the whole course of antibiotics

27
Q

What are painkillers

A
  • Used to treat symptoms, pain, and do not kill pathogens
28
Q
  • How can plants be used to create drugs
A
  • Plants produce variety of chemicals to defend themselves
  • Can be used as drugs to treat humans or relive symptoms
  • Some can be extracted from microorganisms
  • Most are made by chemists but they are still used today
29
Q
  • What examples of plants being used for medication can be seen today
A
  • Aspirin- painkiller to lower fever. Found in willow

- Digitalis- Used to treat heart conditions- Found in Foxgloves

30
Q

What was Alexanders Flemming’s discovery

A
  • Was clearing out petri dishes containing bacteria
  • One of dishes had mould, but area around mould was free of bacteria
  • Mould called penicillium notatum was producing substance that killer bacteria
  • Penicillin
31
Q

What are the three stages in drug testing- breif

A
  • Pre-clinical 1- tissue
  • Pre-clinical 2- animals
  • Clinical- humans
32
Q

Describe the first stage of drug development

A
  • Preclinical-
  • Tested on human cells and tissues
  • Can’t use humans cells or tissue to test drugs that affect whole or multiple systems
  • E.g Blood pressure drug has to be done on whole animal
33
Q
  • Describe the second stage in drug development
A
  • Pre-clinical 2
  • Animals
  • Test efficiency, toxicity and dosage
  • Law in Britain means new drug has to be tested on two live animals
34
Q

What are efficiency, toxicity and dosage - drugs

A
  • Efficiency- Wether it works or not and produces desired effect
  • Toxicity- How harmful drug is
  • Dosage- Concentration and frequency at which the drug should be given
35
Q

What are contrasting views on Animal testing

A
  • Some people say its cruel and wrong.
  • Animals don’t get the choice
  • Animals are different to humans so its pointless
  • Some say its the safest way
  • Better for animals to be harmed than humans
36
Q

What is the third stage in Drug development

A
  • Clinical testing
  • Tested on voluntary, healthy volunteers- side effects
  • Starts with very low dose
  • optimum dose found with further trials
  • If Safe it gets tested on sufferers on illness-
  • Goes through peer review and published
37
Q

What is an optimum dose

A
  • A dose that produces the greatest effect with the fewest side effect
38
Q

What is a placebo

A
  • A substance that is like the drug but does nothing
39
Q

What is the placebo effect

A
  • Where someone expects the treatment to work and feel better, even though nothing is happening
40
Q

What is meant by a blind trial

A
  • Patients don’t know if they are getting the drug or placebo
  • Allows to compare actual results to pleb results
41
Q

What is a double blind trial

A
  • Where neither the patient to the doctor know wether or not they have been given the placebo till the end
  • stops sub-conscience influencing of testers