Autonomic nervous system- Neuroanatomy Flashcards
Sym preganglionic neurons synapse on ———– cells of adrenal medulla and secrete ———-as NT that binds to N<strong>2</strong> R’s.
Chromaffin cells of adrenal medulla
Secrete ACh binds to N2 Receptors.
N2’s are a type of Cholinergic receptors( Cholinergic- nicotinic).
wide spread action of SNS via
causes globalization of sympathetic reaction
Adrenal medulla
3 general locations of nicotinic receptors
1- N2 -Nn- Autonomic ganglia
2- Nn-Adrenal medula
3- Nm- Neuromuscular Junction
The absence of this enzyme leads to the production of NE only in sympathetic postganglionic neurons (sym. post.gng nn’s):
PNMT- phenylethanolamine
ß1 produces/causes:
Excitation
Activation of nicotinic receptors cause:
Excitation
Ion- channels for Na+/K+
all neurons that conduct SENSORY information from viscera are located in
peripheral ganglia- either dorsal root or cranial nerve ganglia
The effect of SNS on the skin’s arrector muscle, peripheral bv, and sweat glands:
Hairs stand out
Blood vessels constrict- vasoconstriction
Sweat glands secret (sweating)
Autonomic center(s) of pons
pneumotaxic center
Part of respiratory center, the other two parts are located in medulla.
à1 adrenergic receptor Location:
G-protein:
Mechanism of action:
smooth muscles
Gq
Inc. IP3/[Ca2+]
ß2 produces
Relaxation-Dilation
- Relaxation of vascular smooth muscles
- Dilation of bronchioles
- Relaxation of bladder wall
The effect(s) of sysm. tone on the:
1- SNA node and HR
2- AV nodal conduction
3- contractility
Increase for all three under sympathetic tone.
Inc. HR
Inc. AV nodal conduction
Inc. contractility
The only division that exerts control over the vasomotor functioning of the vessels of the body wall
Sympathetic division
Autonomic center(s) of midbrain:
- Name an example
Micturition center
(Beta-2) ß<strong>2</strong> adrenergic receptor Location:
G-protein:
Mechanismof action:
- smooth muscles
- Gs
- Inc. [cAMP]
vasodilation is typically elicited by this division of ANS
Parasympathetic
à-Receptor affinity fo NE and EPI
Greater affinity for norepinephrine
N.E. > EPI
Activation of B2 receptors of skeletal muscles’ b.v.:
Sympathetic tone →
Stimulates B2⇒ vasodialation in skeletal muscle
(blood vessels of the skeletal muscles).
Contractility of the heart under parasym. influce:
The receptor for the parasym division is M- muscarininc
Reduction of contractility- ATRIA
Innervation of the chemoreceptors and baroreceptors of the aortic arch:
GVA
Parasympathetic/ CN X
CNIII
parasym. Preg. neuron
oculomotor
Symp. action in the kidney and fat cells
(B1 adrenergic receptors)
- Kidney- inc. renin secretion
- Fat cells- inc. lipolysis
Parasym. tone causes the ———– of detrusor muscle and ———- of the internal sphincter of the bladder.
Contraction of the detrusor muscle
Relaxation of the internal sphincter.
“full” state
Parasympathetic function of CN X
visceromotor
Result of the binding ATP to its receptors (P2x)
Rapid contraction of smooth muscle
Tension of vascular smooth muscle
Ionotropic- inflow of Ca2+ and Na+
Stimulation of M3 R’s of the smooth muscles of GI tract leads to:
M3 stimulation (for both glands and smooth muscles) has excitatory effects
M3 activation ⇒ Increased GI motility
Stimulation of M3 R’s leads to ——— of glands.
M3 stimulation of both glands and smooth muscles of GI has excitatory effects.
M3 activation ⇒ increased secretion
Ganglion associated with glossopharyngeal nerve
otic ganglion
The center for conscious perception
cerebral cortex
-Regulates hypothalamus, which in turn regulates cranial nerve and spinal cord mediated autonomic activities.
Mechanism of action of B2 and B1
both via GPCR- Gs proptein –>stimulation of adenylate cyclase (AC) –> Inc. cAMP
Parasympathetic Efferent cranial nerves
CN IX and X carry significant amt of parasym afferent
The postgnanglionic n. branching from submandibular ganglion innervates
innervates submandibular and sublingual glands
Degrades cGMP
cGMP phosphodiasterase
Primary NT of preg. neurons of SNS and PNS
ACh- Acetylcholine
The dominant ANS division during “filling” state of bladder:
* status of the detrusor muscle and the internal sphincter
sympathetic is dominant
detrusor muscle- relaxed (B2 R)
internal sphincter- constricted (a1 R).
2 compounds that activate nicotinic receptors
ACh and nicotine
SNS effects on the heart
HR, contraction strength and coronary vessels
- Inc. HR
- Inc. contraction strength
- In coronary vessel - SNS inhibits PNS
- PNS inhibition ► Allows dilation (exception)
carotid sinus and body impulses are carried to medulla via:
Sinus- glossopharyngeal nerve
Body- vagus nerve
Sinus- localized dilation of internal carotid artery at its origin(resp to inc.dec BP).
Carotic body- chemoreceptor- mainly responds to changes in arterial o2 and co2. impulses are carried by vagus nerve.
Sympathetic effect on the radial muscles of the iris
SNS causes pupil dilation
Stimulation/activation of a1 receptors in blood vessels of skin and splanchnic:
Sympathetic → a1 stimulation → bv constriction in skin and splanchnic.
M3 R’s (cholinergic_muscarinic receptors) of the smooth muscles and the GI glands are activated by
ACh and muscarine
Mechanism when B1 produces excitation in the heart
Examples of B1 excitation: inc. HR, inc. conduction velocity, and inc. contractility
GPCR- Gs protein → adenylate cyclase (AC) →
Inc. [cAMP] ► inc. ( HR, conduction velocity, and contractility)
The effect of nicotine on N2 and N1 R’s:
Nicotine is agonist to both
(N2 receptor is different from neuromuscular N1).
Location of muscarinic receptors:
- PNS division
- heart (M2)
- smooth muscles (M3)
- glands (M3)
The sysmpathetic post-ganglionic receptors of the sweat glands are also muscarinic (exception).
Mechanism of action of sweat gland’s muscarinic R’s (SNS):
Inhibition of adenylyl cyclase ⇒ dec. [cAMP]
The type of vascular smooth muscles regulated during secretion
Unitary
The effect of PNS on the Heart:
HR, Contraction strength and coronary vessel
- Reduced HR-
- Reduced Contractile strength
- Coronary artery constricts
In general, reduced demand for the heart
Muscarinic receptors are generally found in:
Effector organs of PNS
B1 response and mechanism of action
GPCR-Gs
sensitive to both epi and norepi
a2 mechanism of action
Gi-GPCR
inhibition of adenylate cyclase (AC)- dec. cAMP
a1 mechanism of action
Gq-GPCR → stimulation of PLC → Inc IP3 /Ca2+
Nicotinic (cholinoreceptor) mechanism of action:
Via depolarization opening of Na+/K+ channel
parasympathetic visceral sensory pathway
from pelvic viscera travel in spinal n. through ventral root
symp. action in bladder via B2 and a1 R’s
B2-relaxes the wall a1- const. sphincter
Ganglion associated with occulomotor
ciliary ganglion
The effect of PNS on the M3 R’s ofGI tract
M3- increased motility M3- sphincter relaxation
Beta-1 (B1) adrenergic receptor Location: Gprotein: Mechanism:
heart Gs IInc. cAMP
epinephrine synthesis in adrenal medulla
Tyrosine –> L-dopa –> Dopamine –> Norepinephrine –> epinephrine
Visceromotor function of CN X influences
thoracic and abdominal viscera up to the first 2/3 of the colon
autonomic center(s) of hypothalamus
temp reg center thirst-food intake regulation center.
Viagra mode of action
prolongs cGMP action by inhibiting the cGMP phosphodiasterase
autonomic centers of medulla
vasomotor center respiratory center swallowing, coughing and vomiting center
Primary NT of postgang. neurons SNS
NorEpi, neurons to sweat glands- Ach
parasym. action in bladder via M3 receptors
M3- contraction of the wall M3- relaxn of the internal sphincter
SNS impact in glands other than sweat
indirect- vasoconstriction
pupil- PNS
pupil constriction - retina protection
Cholinergic receptor-Nicotinic-N2 (Nn) Location: Gprotein: Mechanism:
Autonomic ganglia (NEJ- Neuro effector juction) - opening of Na+/K+ channel
a2 receptors- adrenergic- location and impact
located on sym postgang nerve terminal, platelets, fat cells and the walls of GI tract Gi- Inhibition
binding of —— to Guanylyl cyclase (GC) activates this E in smooth muscle and leads to
NO + GC –> Active GC —> first phase of muscle relaxation