Autonomic nervous system drugs

Question 1

Where are alpha one receptors located?

Answer 1

α1 – blood vessels, bladder (post-synaptic)

Question 2

What is the function of α2 receptors ?

Answer 2

α2 - inhibits Norepinephrine release (pre-synaptic)

Question 3

Where is B1 located ?

Answer 3

β1 - heart (rate, force), kidney (renin)

Question 4

Where is b2 located ?

Answer 4

β2 - lung (bronchodilation), skeletal muscle (vasodilation), GI tract (motility↓, sphincter close)

Question 5

Where is B3 located ?

Answer 5

β3 - bladder (relaxation)

Question 6

What medication can be used for nasal decongestants ?

How does it do this ?

What class of medication is it ?

Answer 6

• Phenylephrine
• Oxymetazoline

Alpha-1 adrenoceptor agonists include oxymetazoline, which are used as nasal decongestants through the constriction of nasal blood vessels.

Question 7

Name two different alpha 1 adrenoreceptor ANTAGONIST.

What do they do?

Answer 7

As it is an antagonist, they relax!

Antihypertensive - Doxazosin by decreasing peripheral resistance.

Treatment of urinary retention - Tamsulosin. This works by relaxing the bladder, neck, and prostate muscles.

Question 8

Name some Beta-2 adrenoceptor agonists

Answer 8

SABA - salbutamol

LABA - Salmeterol and fomoterol.

Question 9

What can be used for urinary incontience, explain this.

Answer 9

Mirabergon - B3 agonist

-Relaxes detrusor muscle in the bladder

• Increases bladder capacity in overactive bladder

Question 10

Name a the B1-adrenoceptor ANTAGONIST?

Answer 10

bisprolol