Alzheimers

Question 1

How do acetylcholinesterase (AChE) inhibitors work ?

Answer 1

Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine in the brain. As a result, an increased concentration of acetylcholine leads to increased communication between nerve cells.

Question 2

What are the three acetylcholinesterase (AChE) inhibitors ?

Answer 2

Donepezil
Rivastigmine
Galantamine

Question 3

How do NMDA receptor antagonists work in Alzheimers?

Answer 3

In alzhiemers excessive NMDAR activity causes excitotoxicity and promotes cell death,

NMDA receptor antagonist bind directly to the glutamate site of the NMDA receptor to inhibit the action of glutamate.

Question 4

Name a NMDA receptor antagonist

Answer 4

Memantine