Anticoagulant

Question 1

what does DOAC stand for ?

Answer 1

Direct oral anticoagulants (DOACs)

Question 2

What type of medication is APIXIBAN, RIVAROXABAN, EDOXOBAN ?

How does it work ?

When is it used ?

Answer 2

DOAC

Inhibition of factor Xa

• VTE
  -DVT
• AF

Question 3

What is warfarins mechanism of action?

Answer 3

Vitamin K Antagonist- prevents activation in coagulation cascade
of factors II (prothrombin), VII, IX & X

Question 4

What is a normal prothrombin time ?

Answer 4

Prothrombin time in healthy humans
12-13 seconds)

Question 5

What is the normal patient INR?

Answer 5

2-3 seconds

Take at dinner time measure INR (2-3), 2-3 days to work, for DVT treat for 6 months

Question 6

When is warfarin commonly used ?

Answer 6

Heart valve replacement

Question 6

What do all of these tablets represent in mg ?

Answer 6

Take at dinner time measure INR (2-3), 2-3 days to work, for DVT treat for 6 months

Question 7

What is the antidote for warfarin?

Answer 7

Vitamin K

Question 8

What family does heparin come under?

How does heparin work?

What is the difference between heparin and LMW heparin?

Answer 8

mucopolysaccharides

Bind to and activate antithrombin III and this then inactivates factor Xa and thrombin.

The low MW heparins, enoxaparin and dalteparin, also bind to factor Xa but not to thrombin.