AUTONOMIC - CHOLINERGICS Flashcards
neurotransmitter located at the ganglions and the parasympathetic terminal nerve endings. It innervates the receptors in organs, tissues, and glands.
Acetylcholine (ACh)
The two types of cholinergic receptors
Muscarinic Receptors
Nicotinic Receptors
inhibit the action of the enzyme cholinesterase (ChE) by forming a chemical complex, thus permitting acetylcholine to persist and attach to the receptor.
Indirect-acting cholinergic drugs
To treat urinary retention, abdominal distention
Bethanecol CI
For GERD and gastroparesis. Central dopamine receptor antagonist. Increases gastric emptying time.
Metoclopramide
To reduce intraocular pressure (IOP), miosis
Carbachol
Pilocarpine
To improve memory in mild to moderate Alzheimer’s demetia. Drug enhances cholinergic functions
Tacrine HCI
Used to treat confusion (dementia) related to Alzheimer’s disease
Donepezil HCI
Used to manage and treat neurodegenerative disease, specifically dementia, in patients with Alzheimer’s and Parkinson disease
Rivastigmine
Indirect-Acting Cholinergics or Cholinesterase Inhibitors for the Eye
Demecarium bromide
To reduce IOP in glaucoma; long-acting miotic
Echothiophate iodide
To reduce IOP; long-acting miotic
Isoflurophate
To treat glaucoma. Apply to the conjunctival sac
To increase muscle strength in myasthenia gravis; long-acting. May be used with glucocorticoids
Ambenomium Cl
To diagnose myasthenia gravis; very short-acting
Edrophonium Cl
To increase muscle strength in myasthenia gravis; short-acting. Used also to prevent or treat postoperative urinary retention
Neostigmine
To reduce IOP, miosis; short-acting
Physostigmine salicylate
To increase muscle strength in myasthenia gravis; moderate-acting. Prevents destruction of the neurotransmitter acetylcholine
Pyridostigmine bromide
