Autoimmune Insulin Dependent Diabetes Flashcards
1
Q
What is wrong with the insulin treatment for T1D?
A
does not accurately mimic physiology so patients are at risk of hypoglycaemia
2
Q
What treatment for T1D minimises the risk of hypoglycaemia?
A
islet transplant
3
Q
How many beta cells are lost before T1D is clinically apparent?
A
80-90%
4
Q
What autoantibodies are present in T1D?
A
insulin, glutamic acid decarboxylase, islet cell, zinc transporter
5
Q
Are the autoantibodies in T1D pathogenic?
A
no
6
Q
What mediates beta cell destruction in T1D?
A
T cells - via perforin and granzyme
