Assessment 3, Part 3 Flashcards
where does platelet production occur?
in the red bone marrow
what is THPO
thrombopoietin: protein that stimulates that growth and division of cells
what is hemostasis?
stoppage of bleeding
what are the 3 stages of hemostasis?
- vascular spasm
- plug formation
- blood clotting cascade/coagulation
What is the vascular Spasm stage of hemostasis?
a reflex initiated by local pain receptors leading to vasoconstriction of damaged blood vessels, reducing blood loss
what is the platelet plug formation stage of hemostasis?
platelets aggregate and adhere to each other and secrete PDGF ADP, and Thromboxane A2.
PDGF is platelet-derived growth factor, ADP is adenosine diphosphate and Thromboxane A2. ADP causes platelets to become sticky. Thromboxane A2 is an eicosanoid.
what is the coagulation stage of hemostasis?
the process of blood clotting that requires so many blood clotting factors that activate one another
what are most blood clotting factors secreted by?
LIVER
which blood clotting factors are not activated by the liver? what are they secreted by instead?
factor 3 “thoromboplastin”= perivascular tissue
factor 8 “fibren-stabilizing-factor”= platelets
what is hemophilia?
failure of blood to form clots
what is hemophilia A?
lack of blood clotting factor #8
what is hemophilia B?
lack of blood clotting factor #9
what is hemophilia C?
lack of factor #11
what is the epicardium of the heart?
the visceral pericardium; the layer of the serosa membrane that covers the heart
what is the myocardium of the heart?
the cardiac muscle cells “cardiocytes”
what is the endocardium?
simple squamous epithelial tissue “endothelium”
what is the visceral pericardium?
the inner layer of the serosa membrance