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Year 2 Pharmacology > Arthritis Drugs - NSAIDs and Analgesics > Flashcards

Arthritis Drugs - NSAIDs and Analgesics Flashcards

1
Q

Loss of cartilage and bone from articulating surfaces

A

Osteoarthritis

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2
Q

Systemic auto-immune disorder, may affect other tissues

A

Rheumatoid Arthritis

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3
Q

Celecoxib

Etoricoxib

A

Cox2 Inhibitors

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4
Q

Cox2 Inhibitors

A

Used mainly in patients at high risk of GI side effects

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5
Q

Side effects of Cox2 Inhibitors

A

Headaches, dizziness, skin, rash, oedema

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6
Q

Synthetic Prostaglandins

A

Misoprostol

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7
Q

Misoprostol

A

Given along side NSAID
Preserves mucous lining of GI tract
Protects against ulceration
Stimulating abortion

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8
Q

Side effects of Misoprostol (synthetic PG)

A

Diarrhoea, Vaginal Bleeding

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9
Q

Early Cox 2 Inhibitor

A

Meloxican

Rotecoxib

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10
Q

Side effects of early Cox2 Inhibitors

A

CV complications

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11
Q

NSAID

A

Asprin

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12
Q

Asprin

A

Rapidly absorbed in stomach
Displaces warfarin bound to plasma protein - ^ plasma warfarin
Negatively charged

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13
Q

Side effects of NSAID

A 
Gastric ulcers 
Impaired co-agulation 
GI bleeding
CV events 
May induce asthma attack 
Skin rash 
Kidney damage 
Liver damage
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14
Q

Analgesic/Antipyretic

A

Paracetamol

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15
Q

Paracetamol

A

Not a NSAID

No anti-inflammatory effect

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16
Q

Side effects of paracetamol

A

Kidney damage

Liver damage

17
Q

Oesteoarthritis treatmen t

A

Strontium Renelate

18
Q

Strontium Renelate

A 
Osteoarthritis 
Promotes osteoblasts 
Inhibits osteoclast activity 
Reduces pain 
Prevention of serve fractures
19
Q

Side effects of Strontium Renelate (osteoarthritis)

A

Risk of MI

Risk of thrombotic events

20
Q

Glucosamine Sulphate

A

Major constituent of ECM

Present in cartilage + synovial fluid

21
Q

Hydiocortisone
Corticosterone
Aldosterone

A

Natural steroids

22
Q

Celecoxib is a ? inhibitor

A

COX 2 selective

23
Q

Celecoxib is thought to have a reduced risk of causing..

A

Gastric Ulcer

24
Q

Common side effect of cyclophosphamine treatment

A

Haemorrhagic cystitis

25
Q

What is the proposed mechanism for the gastric bleeding associated with use of NSAIDs?

A

Inhibition of COX 1

26
Q

Methotrexate is a cytotoxic drug used to treat rheumatoid arthritis, its mech of action reduces synthesis of what?

A

Folic acid

27
Q

Examples of NSAID’s

A

Ibuprofen
Aspirin
Diclofenac
Meloxicam

28
Q

Examples of Corticosteroids

A 
- Mixed guco/minercoricoid 
Prednisolone 
- Glucocorticoid 
Dexamethasone, Betamethasone, Bedamethasone, Budenoside 
-Minercocorticoid 
Fludrocortisone
29
Q

Examples of immnosupressants

A 
Ciclosporin
Azothioprine 
Methotrexate 
Leflunomide
Cyclophosphaide
30
Q

Sulfasalazine
Pencillamine
Gold Compounds
Anti malarials

are examples of

A

Disease-modifying anti-rheumatoid drugs (DMARDS)

31
Q

Examples of anticytokines

A

Eternercept
Inflixiab
Rituximab
Abatacept

Year 2 Pharmacology (12 decks)

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