Antifungals

Question 1

Anti fungal drugs target

Answer 1

Fungal specific processes/structurs

Question 2

The fungal CW has

Answer 2

Skeletal and matrix components

Question 3

Skeletal CW components

Answer 3

Glucan

Chitin

Question 4

Current anti fungals that target cell wall are

Answer 4

Inhibitors of b1-3 glucan biosynthesis

Question 5

What is the target for the currently used anti fungals

Answer 5

Pm

Question 6

Pm in fungal cells contain

Answer 6

Ergosterol (without this fungal cells will not survive)

Those of human cells contain cholesterol

Question 7

Echinocandins

Caspofungin
Micafungin

Answer 7

Inhibit the enzyme b1-3 glucan synthetase
Block synthesis of b1,3 glucan
Drugs are fungicidal

Question 8

Polyene anti fungals

Amphotericin b
Nystatin

Answer 8

Bind to resident Ergosterol

Prolong use = kidney failure

Question 9

Mycoses

Answer 9

Disease caused by fungi

Question 10

Azoles anti fungal

Imiadzoles
Triazoles

Answer 10

Inhibit enzyme lanosterol c-14

Blocks Ergosterol

Question 11

Allylamines

Teraiafine
Amorolfine

Answer 11

Inhibit earlier step Azoles

Question 12

Flucytosine

Answer 12

DNA RNA synthesis

Used with Azoles

Fungal cell turn into 5-fu which inhibits NA synthesis