ARNIs (HF) Flashcards
1
Q
What system is associated with ARNIs?
A
natriuretic peptide system
2
Q
How do ARNIs work?
A
inhibit neprilysin and AT1 angiotensin II receptors
3
Q
What does inhibiting neprilysin increase?
A
angiotensin II
4
Q
How is the increase in angiotensin managed?
A
using ARBs
5
Q
When are ANRIs used?
A
as an OPTION for:
- NYHA 2-4 with LVEF <35%
- symptomatic even after taking a STABLE dose of ACEIs or ARBs
6
Q
adverse effects
A
hypotension
hyperkalaemia
renal impairment
angioedema
7
Q
precautions
A
not with ACEIs or ARBs
not within 36hrs of last ACEI/ARB dose
not to patients with history of angioedema
