ARBs (HF)

Question 1

What do ARBs block?

Answer 1

AT 1 receptors

Question 2

Why are ACEIs blunt instrumants?

Answer 2

there is angiotensin II escape during ACE inhibition

Question 3

What effects does angiotensin II have?

Answer 3

bad effects at AT 1 -> aldosterone release, vasoconstriction, proliferative actions
good effects at AT 2 -> vasodilator, antiproliferative actions

Question 4

What does decreasing vasoconstriction cause?

Answer 4

increases peripheral vasodilation

decrease SVR

Question 5

What does decreasing aldosterone release cause?

Answer 5

decreases plasma volume

Question 6

What does decreasing cardiac proliferative effects cause?

Answer 6

decreases cardiac remodelling

Question 7

UK licenced agents

Answer 7

candesartan
losartan
valsartan

Question 8

Indicated for what patients?

Answer 8

NYHA 2-4 who are intolerant of ACEIs

symptomatic NYHA 2-4 (on ACEI and beta blockers) who can’t tolerate aldosterone receptor antagonist

Question 9

side effects

Answer 9

1st dose hypotension
worsening renal function
hyperkalaemia