ACEIs (HF) Flashcards
What do they do?
- inhibit chronic RAAS activation
- inhibit ACE
What does inhibiting ACE cause?
- decreases angiotensin 2 production
- increases bradykinin activity
Who should take ACEIs?
- patients with LV dysfunction
- asymptomatic with LV dysfunction
- NYHA 2-4
What must you check when taking ACEIs?
- check BP
- renal function
- serum K and Na
2 types of side effects of ACEIs?
- related to suppression of Ang II
- breakdown of bradykinin
Precautions
- 1st dose hypotension
- intolerance
- bilateral renal artery stenosis/renal insufficiency
- low systemic BP
- hyperkalemia
- pregnancy
What does suppression of Ang 2 cause?
- peripheral vasoconstriction
- decreased aldosterone release
What does promotion of bradykinin cause?
- increased peripheral vasodilation
- increased prostaglandin release
What does arteriolar vasodilation cause? (good effect)
decreased hypoperfusion symptoms
What does decreased aldosterone release cause? (good)
decreases congestive symptoms
What symptom must be avoided with ACEIs and what treatment is used for this?
fluid retention
diuretics
Side effects related t suppression of Ang 2 breakdown
- hypotension (1st dose effect)
- worsening renal function
- hyperkalaemia
Side effects related to inhibition of breakdown of bradykinin
- cough
- angioedema
