April 29

Question 1

What is the function of prostacyclin–PGI2?

Answer 1

Increased vascular permeability
Vasodilates
Inhibits platelet aggregation

Works opposite of thromboxane–work together to keep vascular homeostasis

Question 2

What is the cause of Dubin-Johnson syndrome and what causes the liver to become black?

Answer 2

Defective hepatic excretion of bilirubin glucuronides across canalicular membrane

Black liver–Impaired excretion of epinephrine metabolites

Question 3

Anti-smith antibodies seen in SLE are antibodies against what?

Answer 3

Autoantibodies directed against snRNPs–which are essential components of spliceosomes, which remove introns from pre-mRNA to form mature mRNA

Question 4

What is used to control the symptoms of delirium–agitation and psychosis?

Answer 4

High-potency 1st gen anti-pshycotics –Haloperidol

Question 5

What drugs cause decreased production of aqueous humor by the ciliary epithelium in the eye?

Answer 5

Timolol
Acetazolamide
a2-agonists

Question 6

What drugs increase the outflow of aqueous humor through the trabecular meshwork?

Answer 6

Prostaglandin F2a–Latanoprost and travoprost

Cholinomimetics–pilocarpine, carbachol

Question 7

What mediates calcium efflux from cardiac cells prior to relaxation?

Answer 7

Na/Ca exchanger and SR–Ca ATPase (SRCA)

–reuptake of calcium

Question 8

What are the symptoms of DRESS syndrome and what drugs can cause it?

Answer 8

Fever
Generalized lymphadenopathy
Facial edema
Diffuse skin rash
Eosinophilia 
Internal organ dysfunction

Occurs 2-8 wks after introduction to –anticonvulsants, allopurinol, sulfonamides, antibiotics (vanco and minocycline)

Question 9

What causes an isolated increase in bleeding time and is caused by platelet dysfunction?

Answer 9

Uremic platelet dysfunction seen in pts with renal failure

Question 10

1st infection with dengue fever is different compared to 2nd how?

Answer 10

1st infection usually milder symptoms that resolve, but 2nd infection is usually by different viral serotype and causes a more severe illness

Question 11

Pancytopenia with absence of splenomegaly is most indicative of what?

Answer 11

Aplastic anemia

Question 12

Mid systolic click murmur that disappears with squatting is indicative of what?

Answer 12

Mitral valve prolapse –connective tissue defect

Question 13

Leukocyte alkaline phosphatase is decreased in what disease?

Answer 13

CML

Normal or increased with leukemoid reaction