Anxiolytics and hypnotic drugs 4

Question 1

All the following are true about Buspirone EXCEPT:
A) Inhibit 5HT release
B) On 5HT1A as potent agonist on postsynaptic
C) Has only anxiolytic effect
D) Not facilitate action of GABA

Answer 1

B) On 5HT1A as potent agonist on postsynaptic

{ presynaptic }

Question 2

T OR F/ Buspirone cause less sedation and drowsiness

Answer 2

T

Question 3

T OR F/ Buspirone interact with alcohol

Answer 3

F { no interaction }

Question 4

It’s anxiolytic effect appear after (2-4) weeks so It’s used only for chronic anxiety state, not useful in acute, severe form of anxiety as panic attacks?

A) Zaleplon
B) Flurazepam
C) Buspirone
D) Flumazenil

Answer 4

C) Buspirone

Question 5

All the following drugs can be used in panic attack EXCPT:
A) Buspirone
B) Diazepam
C) lorazepam
D) chlorazepate

Answer 5

A) Buspirone

Question 6

Mention the side effect of Buspirone?

Answer 6

Nausea, headache, drowsiness, minimal Sedation

Question 7

Mention hypnotic drugs used to reduce sleep latency with no rebound insomnia on abrupt withdrawal?

Answer 7

1) Ramelteon { Melatonin receptor agonists }
2) Zaleplon { Z-Compounds }

Question 8

All the following are true about Melatonin receptor agonists EXCPT:
A) Rapidly absorbed after oral administration
B) Reduce sleep latency
C) prescribed specifically for patients having difficulty in falling asleep
D) Agonist of MT1 only

Answer 8

D) Agonist of MT1 only

Agonist of MT1 and MT2

Question 9

All the following drugs potentiate the inhibitory effect of GABA EXCPT:
A) Diazepam
B) Buspirone
C) Phenobarbitone
D) Amobarbital

Answer 9

B) Buspirone

Not facilitate action of GABA, (no relation to GABA neurotransmission)

Question 10

Due to their multiple actions, they cause more CNS depression than benzodiazepines and they are less safe and able to produce full general anesthesia?

A) Ramelteon
B) Z-Compounds
C) Barbiturates
D) Melatonin receptor agonists

Answer 10

C) Barbiturates

Question 11

Hyperbilirubinemia and kernicterus in neonate as it induce the hepatic enzymes? (Mention the drug)

Answer 11

Phenobarbital

Question 12

Used for induction of anesthesia and operation of short duration?

A) thiopental
B) amobarbital
C) phenobarbital
D) pentobarbital

Answer 12

A) thiopental

Question 13

Mention advantages of BDZs over barbiturates?

Answer 13

1) Less depressant effect on respiration
2) Less tendency for tolerance, abuse
3) Less tendency for Drug Interactions (not liver enzyme inducers)
4) Less disturbance of REM
5) Higher therapeutic Index
6) Have specific antidote (Flumazenil)

Question 14

Mention the Mechanisms of action of Barbiturates?

Answer 14

1. They potentiate the inhibitory action of GABA as they prolong the duration of opening of chloride channels.
2. Subanesthetic dose they decrease the effect of glutamate on AMPA receptors.
3. Anesthetic dose they block Na+
   conductance.
4. Due to their multiple actions, they cause more CNS depression than benzodiazepines and they are less safe and able to produce full general anesthesia.

Question 15

T OR F / barbiturates Can’t produce full general anesthesia

Answer 15

F { BDZs not Barbiturates }