Anxiolytics and hypnotic drugs

Question 1

• Agonist of benzodiazepine receptors?

Answer 1

• Benzodiazepines :
  1- Short acting BDZs ( t//2 < 6 hrs): Midazolam & Triazolam
  2- Intermediate acting BDZs (t//2 6-24 hrs): Temazepam.
  3- Long acting BDZs: (t//2 > 24 hrs): Diazepam, flurazepam, lorazepam
• Z- Compounds (zaleplon & zolpidem)

Question 2

Agonist of 5-Hydroxy tryptamine (5HT1A)
receptors

Answer 2

Buspirone & ipsapirone

Question 3

-Old drugs

Answer 3

Barbiturates & chloral hydrate

Question 4

-Melatonin receptor agonists

Answer 4

Ramelteon

Question 5

-Drugs which produce sedative effect as side effect

Answer 5

• diphenhydramine
• B. blockers
• Clonidine

Question 6

Clorazepate is?

Answer 6

is inactive (prodrug) and activated in the stomach to active nordiazepam

Question 7

Benzodiazepines (BDZS) not given IM EXCEPT?

Answer 7

lorazepam

Question 8

BZDs are metabolized in the liver by

Answer 8

oxidation, glucouronidation

Question 9

metabolized Diazepam by oxidation?

Answer 9

turn into oxazepam active
metabolite = > prolong their duration of action

Question 10

All benzodiazepines have active metabolites except?

Answer 10

N.O.L.T
nitrazepam
oxazepam
lorazepam
temazepam