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Pharm U3 > Anxiolytics > Flashcards

Anxiolytics Flashcards

1
Q

What is the mechanism of action of all the benzodiazepines

A

GABAa agonist–binds btwn a1 and y2 subunits

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2
Q

Benzodiazepine with a half-life of 43 hrs and has active metabolites up to 100 hrs.

A

Diazepam

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3
Q

What is diazepam used for

A

Short term depression
Maintenance of bipolar, severe bipolar
Anticonvulsant
Muscle relaxant

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4
Q

Benzo with a half life of 10 hrs and has active metabolite up to 100 hrs

A

Chlordiazepoxide

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5
Q

What is chlordiazepoxide used for

A

Short term depression

Maintenance of bipolar and severe bipolar

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6
Q

Benzo with half life of 14 hrs

A

Lorazepam

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7
Q

What is Lorazepam used for

A

Short term depression
Maintenance of bipolar and severe bipolar
Sedation
Anticonvulsant
Prevent withdrawal symptoms in alcoholics

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8
Q

Benzo with half life of 74 hrs and active metabolites up to 100 hrs

A

Flurazepam

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9
Q

What is Flurazepam used for

A

Short-term depression

Maintenance of bipolar and severe bipolar

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10
Q

Benzo with half life of 12 hrs

A

Alprazolam

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11
Q

What is alprazolam used for

A

Short term depression
maintenance of bipolar and severe bipolar
Sedation

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12
Q

Benzo with half life of 1.9 hrs

A

Midazolam

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13
Q

What is midazolam used for

A

Anesthesia–calming effects, production of anterograde amnesia

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14
Q

Benzo with half life of 2.9 hrs

A

Triazolam

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15
Q

What is triazolam used for

A

Short-term depression
Maintenance of bipolar and severe bipolar
Induce sleep

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16
Q

What are the side effects of all the benzos?

A

Daytime sedation and drowsiness
Anterograde amnesia
Synergistic depression of CNS with other drugs
Psychologic and physiologic dependence with chronic use

17
Q

BDZ-1 selective agonist benzo

18
Q

What is zolpidem used for

A

Sedation and hypnosis without muscle relaxation or anticonvulsant activity

19
Q

What are the side effects of zolpidem

A

Sleep walking

Next morning impairment

20
Q

Competitive Non-selective Benzodiazepine antagonist used for benzo overdose

A

Flumazenil

21
Q

Barbiturate that is a GABAa agonist binding to a or b subunit, is highly lipid soluble, fast on and fast off

A

Thiopental

22
Q

What is thiopental used for

A

Induce anesthesia

23
Q

Barbiturate that is a GABAa agonist binding to a or b subunit and is used as an anti epileptic/anticonvulsant

A

Phenobarbitol

24
Q

An anxiolytic drug that has little sedation effect and works through partial agonist at 5HT1A

Pharm U3 (11 decks)

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