Antivirals Flashcards

1
Q

Name some RNA viruses

A

Influenza
HIV
Hepatitis C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is influenza A?

A

Birds and some mammals
Antigenic drift and shift
Seasonal epidemic
Pandemic potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is Influenza B?

A

No animal reservoir

Lower mortality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is Influenza C?

A

Like the common cold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are some high risk groups for Influenza?

A

Elderly
Airway and Cardiac Diseases
Diabetes
Renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Explain the life cycle of a virus

A

Gets absorbed into host cell by Endocytosis
Transported through cytoplasm in an endosomal vesicle
Vesicle is uncoated
RNA replication and synthesis of viral proteins
Assembly of RNA and viral protein
Budding of new particle out of cell
Release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do Amantanades work?

A

M2 ion channel blocker
M2 channel is needed to transport protons into virion
This disintegrates the virion and allows RNA replication and viral protein synthesis
By blocking it, you stop the virion from disintegrating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does Amantanade work on?

A

Influenza A only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are ADRs of Amantanades?

A

CNS effects

Renal effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How does Neuraminidase work in viral replication?

A

Allows virion to be released from the cell

Also increases mobility of virion through mucus in the resp tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What do Neuraminidase Inhibitors work against?

A

Influenza A and B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the ADRs of Neuraminidase inhibitors?

A

Nausea and vomiting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are some examples of Neuraminidase Inhibitors?

A

Zanamavir

Oseltamivir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is a major problem with regard to Amantandes and Neuraminidase Inhibitors?

A

Viruses developing Resistance to them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Name some DNA viruses

A

Herpes Simplex
Varicella Zoster
Epstein Barr Virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly