Antimicrobials

Question 1

What are examples of beta lactams?

Answer 1

Penicillin
Cephalosporins
Carbapenems

Question 2

What antibiotics affect protein synthesis?

Answer 2

Amino glycosides
Macrolides
Tetracyclins

Question 3

What antibiotics affect DNA synthesis?

Answer 3

Quinolones

Folic acid antagonists

Question 4

In what situations would you give antibiotics prophylactically?

Answer 4

Peri-operative
Short term: contact with meningitis
Long term: asplenia, immunodeficiency

Question 5

What do you have to consider when prescribing antibiotics?

Answer 5

What the likely cause of infection is?
Which antibiotics are likely to be effective? (Likely susceptibility and 
   Consequences of the the wrong choice)
Efficacy
Cost 
Administration 
Safety

Question 6

What are general ADRs of antibiotics?

Answer 6

Toxicities and drug interactions
Allergic reactions
Impact on normal flora

Question 7

What are the principles of anti microbial stewardship?

Answer 7

Right antibiotic
Right time
Right dose, frequency and duration
Right route

Question 8

What is time dependent killing?

Answer 8

When successful treatment requires prolonged antibiotic presence at the site of infection
But not at a high concentration

Question 9

What is concentration dependent killing?

Answer 9

When successful treatment requires a high concentration of antibiotic at the site of infection
But not for too long

Question 10

What classes of antibiotics affect cell wall synthesis?

Answer 10

Beta lactams

Glycopeptides