Antiretrovirals Flashcards
1
Q
AE: Abacavir
A
Hypersensitivity rxns: fever, rash, malaise, resp, GI sx
2
Q
AE: Didanosine
A
- Peripheral neuropathy
- Pancreatitis
- GI probs
- Insulin resistance
- Retinal changes
- Optic neuritis
3
Q
AE: Emtricitabine
A
Hyperpigmentation of palms & soles (esp dark skin pts)
Generally well tolerated tho compared to other NRTIs
4
Q
AE: Lamivudine
A
Well tolerated compared to other NRTIs
5
Q
Drug interactions: Abacavir
A
Avoid alcohol
6
Q
Drug interactions: Didanosine
A
Tenofovir- avoid concurrent neuropathic drugs
7
Q
AE: Stavudine
A
- Hyperlipidemia
- Peripheral neuropathy
- Inc serum aminotransferase levels
- diabetes
- pancreatitis
- fatal lactic acidosis (more likely with stavudine than other NRTIs)
8
Q
AE: Tenofovir
A
- Renal toxicity
- Dec bone density
- Osteomalacia
Gen well tolerated
9
Q
AE: Zidovudine
A
- Bone marrow suppression
- Nausea/vomiting
- Headache
- Fatigue
- Confusion
- Malaise
- Hepatitis
- Diabetes
10
Q
Drug interactions: Stavudine
A
Avoid concurrent neuropathic drugs
11
Q
Drug interactions: Tenofovir
A
- Lowers serum concentrations of atazanavir
- If combine w/didanosine = CD4+ decline
12
Q
Drug interactions: Zidovudine
A
- Myelosuppression may inc with coadministration of ganciclovir, interferon alpha, ribavirin, and other bone marrow suppressive agents
- Coadmin with doxorubicin or stavudine should be avoided
