2. Antiretrovirals

Question 1

32 year old pregnant woman with HIV comes to here doctor she is currently well managed with Abacravir. What should the doctor to due to her drug regmine.

A.  Keep as is
B. Change to Nevarapine
C. Change to Idinavir 
D. Change to Raltegravir
E. Change to Ziovudine

RFA

Answer 1

ANS. E . Ziovudine- is a NRTI and while not used much it is approved for treatment of pregnant women

A. Keep as is- both are NRTIs but Abacravir has not been harmless to pregnant women or fetuses

B. Nevarapine- is a NNRTI not approved

C. Idinavir- Protease inhibitor not approved

D. Raltefravir-binds to viral intergrase but is note approved

Question 2

A 29 year old man comes to his doctor and complains of abdominal pain and fatigue. On inspection he is notable for yellowish discoloration of skin. The patients history is positive for IV drug use. The doctor prescribes him a drug that is a guano sine nucleoside analog. What side effect should this patient be made aware of?

A. Hyper pigmentation of Soles 
B. Hemolytic Anemia 
C. Pancreatitis 
D. Lipodystrophy 
E. Rhabdomyolysis 

RFA

This from the DLA other Antivirals

Answer 2

ANS. B Hemolytic Anemia- the patient has Hepatitis C and the drug of choice is Ribavirin and the main side effect is hemolytic anemia

A. Hyper pigmentation of soles- emtricitabine

C. Pancreatitis- Didanosine

D. Lipodystrophy- side effect of Stavudine

E. Rhabdomyolysis- Raltegravir