16. MSK Infection-5

Question 1

A 52 year old man comes to his doctor with complaints of a painful rash is on the left side of his body from his umbilicus. He has no complaints of vision loss. Where was the casual agent most likely lying dormant?

A. Trigeminal Ganglion
B. Sacral Ganglion 
C. DRG 
D. VRG
E.  Sympathetic Ganglion

RFA

Answer 1

ANS. C DRG- the patient has Shingles causes by VZV which lies dormant in the DRG.

A. Trigmenial Ganglion- VZV can lie dormant in the Trigemnial ganglion but then there is usually visual symptoms associated. HSV1 lies dormant in the Trigemnial ganglion.

B. Sacral Ganglion- HSV-2

Question 2

A 5 year old child is brought to the doctor with a fever of 103 F for the past. During examination a rash with a centrifugal spread is notice with facial sparing. Lab testing is done with results of a enveloped ds DNA virus. What is true of the most likely casual agent?

A.  Prevented with MMR vaccine
B.  Posses H protein
C. Possess F protein
D. Gains entry with mylein oligodendrocyte glycoprotein
E. Replicates in salivary glands

RFA

Answer 2

Ans. E. Replicates in salivary glands- The patient has Roseola caused by HHV-6 ( High fever, rash with facial sparing) this virus replicates in in Leukocytes and the salivary glands and uses CD46 receptors

A. Prevented with MMR vaccine- HHV-6 is not prevent by MMR

B. Possess H protein- Rubeola virus (neg. sens enveloped) H protein absorption the virus to cells. rebeola causes Measles symptoms would be first Koplik spots then rash, with the 3 C’s (Cough, corzya, Conjunctivitis

C. Possess- F protein- Rubeola virus, fusion to host membranes,

D. Gains entry with mylein oligodendrocyte glycoprotein- describes Rubella causes by Rubivirus( pos. sense RNA virus). Measles and Roesola use CD46 for entry. Symptoms of rubella are low grade fever, conjunctivitis, sore throat, centripetal spread rash.