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Psychiatry AM > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

What are the indications for use of antipsychotics?

A 
Scizophrenia
Schizoaffective
Bipolar
Psychotic depression
Resistant anxiety
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2
Q

What are the adverse effects of antipsychotics?

A

Tardive dyskinesia
Neuroleptic malignant syndrome
Extrapyramidal side effects

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3
Q

What is tar dive dyskinesia?

A

Involuntary muscle movements that may not resolve with duscontinuation

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4
Q

What are the signs and symptoms of neuroleptic malignant syndrome?

A 
Muscle rigiditiy
Fever
Altered mental status
Autonomic instability
Elevated WBC, CPK and LFTs
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5
Q

What are the extrapyramidal side effects?

A

Acute dystonia
Parkinson syndrome
Akathisia

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6
Q

What agents cause extrapyramidal side effects?

A

Anticholinergic
Dopamine facilitators
BBs

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7
Q

What are the drug types of antipsychotics?

A

Typicals

Atypicals

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8
Q

What are typical antipsychotics?

A

D2 dopamine recepto antagonists

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9
Q

What are the 2 types of D2 dopamine recepto antagonists?

A

High potency

Low potency

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10
Q

What are the pros and cons of high potency D2 dopamine recepto antagonists?

A

High affinity for D2 receptors and less drug interaction

High chance of extrapyramidal side effects

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11
Q

What are the pros and cons of low potency D2 dopamine recepto antagonists?

A

Fewer extrapyramidal side effects

Interact with nondopaminergic receptors

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12
Q

What are atypical antipsychotics?

A

Serotonin dopamine 2 antagonists

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13
Q

What are examples of serotonin dopamine 2 antagonists?

A 
Risperidone
Olanzapine
Quetiapine
Aripiprazole
Clozapine
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14
Q

What are the side effects of riseperidone?

A

Dose dependent extrapyramidal

Dose dependent sedation and weight gain

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15
Q

What are the side effects of olanzapine?

A

Dramatic eight gain

Hypertriglyceridaemia, hypercholesterolaemia and hyperglycaemia

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16
Q

What is the main side effect of quetiapine?

A

Abnormal LFTs

17
Q

What are the side effects of aripiprazole?

A

Drug interactions

akathisia

18
Q

When is clozapine used?

A

Treatment resistant patients because of side effects

19
Q

What are the side effects of clozapine?

A

Dramatic weight gain
Hypertriglyceridaemia, hypercholesterolaemia, hyperglycaemia
Non ketotic hypersomolar coma and death

Psychiatry AM (16 decks)

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