Antipsicoticos Flashcards

1
Q

Fármaco antipsicótico derivado fenotiazinico

A

Clorpromazina

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2
Q

Mecanismo de acción clorpromazina

A

Fármaco antipsicótico derivado fenotiazinico
Antagonista receptor D2 dopamina en encéfalo
Disminución hormonas hipotalamicas e hipofisiarias

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3
Q

Toxicidad clorpromazina

A

Síntomas extrapiramidales: acatisia, diatónica, rigidez muscular, sx neuroleptico maligno, parkisonismo, discinecia)
Efectos anticolinergicos
Sedación
Disfunción erectil, Amenorrea

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4
Q

Fármaco antipsicótico butirofenonas

A

Haloperidol

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5
Q

Mecanismo de acción haloperidol

A

Antagonista receptor D2 dopamina en encéfalo

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6
Q

Toxicidad haloperidol

A

Extrapiramiladismo, anticolinergicos, sedación, disfunción erectil, amenorrea

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7
Q

Fármaco antipsicótico dibenzodiazepina

A

Clozapina

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8
Q

Mecanismo de acción clozapina

A

Fármaco antipsicótico dibenzodiazepina

Bloqueo D2 y D1 dopamina, noradrenolitico, anticolinergico, antihistamínico, inhibición mecanismo de alerta

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9
Q

Toxicidad clozapina

A

Agranulocitosis y disminución del umbral convulsivo

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10
Q

Fármaco antipsicótico tienobenzodiazepina

A

Olanzapina

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11
Q

Mecanismo de acción olanzapina

A

Antipsicótico

Antagonismo receptores tipo 2 dopamina y serotonina

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12
Q

Toxicidad olanzapina

A

Ganancia ponderal

Disminución umbral convulsivo

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13
Q

Fármaco antipsicótico dibenzotiazepina

A

Quetiapina

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14
Q

Mecanismo de acción quetiapina

A

Antipsicótico

Antagonista D1 D2 dopamina, H1 histamina, adrenergicos A1 y A2, 5HT2 serotonina

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15
Q

Toxicidad quetiapina

A

Hipotension

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16
Q

Mecanismo de acción Litio

A

Antipsicótico

Inhibición D2 dopamina
Alteración transporte de cationes en células nerviosas y musculares
Modificación recaptura de serotonina y norepinefrina

17
Q

Toxicidad litio

A
Temblor fino 
Aumento peso
Poliuria 
Nefrotoxidad
Hipotiroidismo 
Cambios EKG
Teratogenicidad —> anomalía de Ebstein
18
Q

Teratogenicidad de litio

A

Anomalía de Ebstein