Antiparkinsons & Alzheimers Drugs 17

Question 1

Acetylcholine ACH

Answer 1

Excitatory neurotransmitter in the basal ganglia

Question 2

Basal ganglia

Answer 2

Group of cell bodies located within the cerebrum involved in regulation of skeletal muscle tone and body movement

Question 3

Bradykinesia

Answer 3

Slowed body movements

Question 4

COMT

Answer 4

Catechol-O-methyltransferase the enzyme that metabolizes dopamine both peripherally and in the brain

Question 5

Dopa decarboxylase

Answer 5

Dihydroxyphenylamine decarboxylase the enzyme that metabolizes the peripheral conversion of levodopa to dopamine

Question 6

Dopamine

Answer 6

Inhibitory neurotransmitter in the basal ganglia

Question 7

Dyskinesia

Answer 7

Abnormal involuntary body movements

Question 8

Dystonia

Answer 8

Muscle spasms, facial grimacing, and other involuntary movements and postures

Question 9

MAOB

Answer 9

monoamine oxidase B, the enzyme that selectively metabolizes dopamine in the brain

Question 10

Muscle rigidity

Answer 10

A stiffness and inflexibility of movement

Question 11

On off phenomenon

Answer 11

Alternating periods of movement mobility and immobility

Question 12

Parkinsonism

Answer 12

Symptoms of Parkinson’s disease, which include resting tremor, muscle rigidity, and disturbances of movement and postural balance

Question 13

Parkinson’s disease

Answer 13

Movement disorder of the basal ganglia caused by a deficiency of dopamine

Question 14

Postural instability

Answer 14

Inability to maintain upright erect posture

Question 15

Tremor

Answer 15

A trembling and involuntary rhythmic movement