Antimicrobials and Caries Risk Assesment Flashcards
: harmful to patient
Adverse effect
: patient’s ability, desire, and motivation to use a product
Compliance
ability of an agent to absorb to teeth and surfaces and be released at therapeutic levels
Substantivity:
: may be harmful, useful, or beneficial
Side effect
pleasant taste and sensation, decrease in microorganisms, halitosis control
Cosmetic:
reduction in plaque, gingivitis and/or dental caries
Therapeutic:
Protects consumers from useless or harmful products
Therapeutic claims must be backed with proof
Evaluates Rx and OTC
Food and Drug Administration (FDA)
Advertising OTC and Rx
Federal Trade Commission (FTC)
Program is voluntary
Started in 1930 to “help consumers make wise choices”
Products submitted for seal must have independent, controlled studies to demonstrate effectiveness and safety
Seal is found on consumer products (professional product seal has been phased out)
ADA Seal of acceptance
Is it enough for an antimicrobial to reduce plaque only?
No; must be therapeutic
Used as solvent for active ingredients
High content can cause hyper-keratotic lesions
Possible link to oral cancer? (inconclusive and still heavily debated)
Alcohol
Cytoplasmic poison; causes rupture of cell membrane allowing leakage
Binds to mucins, reducing pellicle formation and inhibiting colonization
Binds to bacteria, inhibiting their adhesion onto teeth
Substantivity: 12-24 hours
12% alcohol
35-40% decrease in plaque and gingivitis
.12%
-Peridex, perio-gard
Cholorohexidine
0.12% CHXAlcohol free (water-based)
Therapeutically equivalent (?)
Evidence suggests it is as effective as AOH-based CHX
Consider as option for those pts who are intolerant of AOH or who might have other risk factors
ALCOHOL-FREE CHLORHEXIDINE
Side effects of \_\_\_\_\_\_: Staining Altered taste Supragingival calculus mucositis
Chlorhexidine
What is the dosage and how many time a day for how long should it be used?
15 ml; Twice daily 30 secs
Most effective anti-plaque agent currently available
Available with prescription only
FDA approved (no longer carries the ADA seal of approval due to a change in the program)
CHX
_____ on established biofilm will have only superficial effects.
is more effective when plaque is removed prior to rinsing.
The biofilm will adapt and protect itself from the effects.
CHX
Inactivated by toothpaste—important to rinse well with water prior to rinsing with it (or wait 30 min before rinsing with it)
DO NOT rinse with water immediately after rinsing with it
Recommend for patients who cannot or will not maintain adequate plaque control
Post (periodontal) surgical cases
CHX