Antimicrobials 9 Flashcards
Folate Antagonists
CELLMETABOLISMINHIBITORS
CELL WHAT ARE THE METABOLISM INHIBITORS
Sulfonamides
Pyrimidines
Sulfones
Sulfamethoxazole + trimethoprim
Co-trimoxazole
Sulfadiazine + trimethoprim
Co-trimazine
preferred for the prevention of infection of burn wounds
Silver sulfadiazine + mafenide
a prodrug of 5-Aminosalicylic acid (5-ASA) widely used in ulcerative colitis, enteritis, inflammatory bowel diseases, and rheumatic arthritis
Sulfasalazine
Sulfadoxine + pyrimethamine
Fansidar®: used in malaria
1st line therapy for acute toxoplasmosis
Sulfadiazine + pyrimethamine
bacterial dihydrofolate reductase inhibitor - Used for acute urinary tract infections
Trimethoprim
inhibit dihydropteroate synthetase
MOA of sulfones
used effectively in the long-term treatment of leprosy
Dapsone
C/l: patients with G6PD deficiency - may cause hemolytic anemia
Dapsone
inhibit dihydropteroate synthetase
MOA of Sulfonamides