Antimicrobials 7-8 Flashcards
WHAT ARE THE 50S INHIBITORS
Macrolides
Lincosamides
Chloramphenicol
“methylated ervthromycin”
Clarithromycin
What are the macrolides drugs
Clarithromycin
Azithromycin
Roxithromycin
Erythromycin
prototype, produced from S. erythraeus,
Erythromycin
use: for the treatment of ulcers caused by H. pylori
Clarithromycin
potent enzyme inhibitors
Clarithromycin & Erythromycin
14-16-membered macrocyclic lactone ring
Macrolides
Other term of Erythromycin
Ilotycin
a prodrug which is more lipophilic >- longer duration of action
ethylsuccinate
A type of pneumonia caused by legionella pneumop
Legionnaire’s disease
sulfur-containing antibiotic
Lincosamides
lipid-soluble, acid-stable prodrug with better oral absorption
estolate
motilin agonist
Erythromycin
isolated from Streptomyces lincolnensis
Lincomycin
from Streptomyces venezuelae
Chloramphenicol
70S Inhibitor
Oxazolidinone antibacterial
idiosyncratic reaction unrelated to dose
aplastic anemia:
old DOC for typhoid fever
Chloramphenicol
A/E C. difficile-induced pseudomembranous colitis
Clindamycin