Antimicrobials

Question 1

irreversibly inhibits transpeptidase by covalently binding to the serine residue of the active site of the penicillin binding proteins (PBPs) thus inhibiting cell wall synthesis

Answer 1

MOA of B-Lactam Antibiotics

Question 2

Old penicillin

Answer 2

Penicillium notatum

Question 3

clinical trials of penicillin

Answer 3

freeze-drying” or “lyophilization”

Question 4

New penicillin

Answer 4

P. chrysogenum or P. rubens

Question 5

Alternative to penicillin if allergic

Answer 5

Erythromycin

Question 6

major product of acid degradation

Answer 6

Penilloic acid

Question 7

Penicillin SAR in the R or side chain: addition of electron withdrawing group

Answer 7

acid stability

Question 8

Penicillin SAR in the R or side chain:
addition of amino group

Answer 8

increases spectrum of activity

Question 9

may be given with Probenecid to improve bioavailability

Answer 9

Penicillin G

Question 10

“Narrow Spectrum” penicillins

Answer 10

Natural Penicillins

Question 11

T/F. Sulfur atom in thiazolidine ring is nonessential

Answer 11

True

Question 12

depot forms if pen G given IM but is rapidly excreted

Answer 12

benzathine penicillin, procaine penicillin

Question 13

major product of enzymatic degradation of penicillin
by B-lactamase

Answer 13

Penicilloic acid:

Question 14

phenoxymethyl penicillin

Answer 14

Penicillin V

Question 15

A natural penicillin given orally and only for minor infections

Answer 15

Penicillin V

Question 16

benzylpenicillin

Answer 16

Penicillin G

Question 17

Penicillin SAR in the R or side chain: addition of bulky group

Answer 17

penicillinase resistance

Question 18

Antistaphylococcal Penicillins

Answer 18

• “Penicillinase-resistant” penicillins

Question 19

Wht are the Antistaphylococcal Penicillins

Answer 19

Methicillin
Nafcillin
Oxacillin

Question 20

• “Broad Spectrum” penicillins

Answer 20

Aminopenicillins

Question 21

can be given to patients with renal problems

Answer 21

Nafcillin

Question 22

• alternative to methicillin

Answer 22

Nafcillin

Question 23

development of bacterial resistance: MRSA—-> vancomycin

Answer 23

Methicillin

Question 24

What are the amino penicillins

Answer 24

Ampicillin
Amoxicillin

Question 25

Also know as oxacillin

Answer 25

“Isoxazolyl” penicillins

Question 26

Prodrugs of ampicillin

Answer 26

Bacampicillin, Hetacillin, Ciclacillin

Question 27

commonly used in respiratory infections given in PO

Answer 27

Amoxicillin

Question 28

DOC: Listeria monocytogenes

Answer 28

Ampicillin

Question 29

What are the Antipseudomonal Penicillins

Answer 29

Carboxypenicillins
Ureidopenicillins

Question 30

An acid labile penicillin given IM or IV

Answer 30

Antipseudomonal Penicillins

Question 31

What are the 4 classification of penicillin

Answer 31

Natural Penicillins
Antistaphylococcal Penicillins
Aminopenicillins
Antipseudomonal Penicillins

Question 32

with urea in the a-position

Answer 32

Ureidopenicillins

Question 33

has the broadest spectrum of the penicillins

Answer 33

Piperacillin +Tazobactam

Question 34

Which of them is the most potent in ureidopencillins: Azlocillin, Mezlocillin, Piperacillin

Answer 34

Piperacillin

Question 35

with Carboxyl group in the a-position

Answer 35

Carboxypenicillins

Question 36

Antibiotic: a substance produced by a microbe that
kills (bactericidal) or inhibits (bacteriostatic) another microbe

Answer 36

Antibacterials

Question 37

“Extended Spectrum” penicillins

Answer 37

Antipseudomonal Penicillins