Antifungal Agents

Question 1

MOA: inhibits lanosterol 14-a-demethylase to block demethylation of lanosterol to ergosterol
synthesis

Answer 1

AZOLE ANTIFUNGALS

Question 2

Clotrimazole brand name

Answer 2

Lotrimin®, Mycelex ®

Question 3

• effective against most fungi that cause superficial and systemic infections

Answer 3

AZOLE ANTIFUNGALS

Question 4

Miconazole brand name

Answer 4

Monistat ®

Question 5

> use: for the treatment of serious systemic fungal infections and chronic mucocutaneous candidiasis

Answer 5

Miconazole

Question 6

Has an A/E if hepatotoxicity

Answer 6

Ketoconazole

Question 7

uses: for the treatment and prophylaxis of disseminated and deep-organ candidiasis

Answer 7

Fluconazole

Question 8

Itraconazole brand names

Answer 8

Sporanox®, Inox®

Question 9

absorption is not affected by alteration in Gl acidity or presence of food

Answer 9

Fluconazole

Question 10

> use: for the treatment of systemic fungal infections

Answer 10

Itraconazole

Question 11

used topically as cream or shampoo (2%) for the management of cutaneous candidiasis and tinea infections

Answer 11

Ketoconazole

Question 12

Fluconazole brand name

Answer 12

Diflucan

Question 13

› alternative to ketoconazole

Answer 13

Itraconazole

Question 14

> available as cream and gel (1%)

Answer 14

Naftifine

Question 15

available as cream, powder, aerosol, gel, and solution (1%)

Answer 15

Tolnaftate

Question 16

MOA: inhibits squalene epoxidase -› inhibits ergosterol synthesis

Question 17

• used for the treatment of tinea pedis, tinea cruris, and tinea corporis

Answer 17

ALLYLAMINES

Question 18

> more potent than naftifine

Answer 18

Terbinafine

Question 19

Tolnaftate brand name

Answer 19

Tinactin®, Aftate®

Question 20

available as cream (1%)

Answer 20

Terbinafine

Question 21

Terbinafine brand name

Answer 21

Lamisil®