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Mechanisms of Disease Exam #3 > Antimicrobials > Flashcards

Antimicrobials Flashcards

1
Q

What type of ABX are bactericidal?

What type of ABX are bacteriostatic?

A
  • cidal: cell wall synthesis inhibitors

- static: protein synthesis inhibitors

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2
Q

Which ABX are bactericidal?

A

B-lactams
Glycopeptides
Lipoglycopeptides

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3
Q

MOA for Glycopeptides

A

Binds to D-Ala-D-Ala on cell wall glycoproteins

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4
Q

MOA for B-lactams

A

B-lactam inhibits PCN binding protein (transpeptidase)

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5
Q

1st generation Cephalosporins cover:

A

G+ cocci - PEK
P. mirabilis
E. coli
Klebsiella

*think UTIs

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6
Q

2nd generation Cephalosporins cover:

A 
G+ cocci - HENS
H. influenzae
Enterobacter
Neisseria
Serratia
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7
Q

3rd generation Cephalosporins cover:

A

G-
Meningitis
PID
GI tract infections

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8
Q

What is the 1st line TX for meningitis?

A

Ceftriaxone

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9
Q

What kind of spectrum for 4th and 5th generation Cephalosporins have?

A

Broad

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10
Q

Major Cephalosporin TX for Pseudomonas:

A

4th gen. -> Cefepime

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11
Q

Major TX for MRSA

A

5th gen. -> Ceftaraline

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12
Q

Vancomycin S/E

A

Red man syndrome

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13
Q

What are the only protein synthesis inhibitors that are NOT bacteriostatic?

A

Aminoglycosides

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14
Q

S/E associated w/ Oxalizolidinones

A

Myeloid suppression

Thrombocytopenia

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15
Q

What is the best TX for atypical pneumonias?

A

Erythromycin - Macrolides

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16
Q

What ABX can cause C diff?

A

Macrolides - Clindamycin

17
Q

What ABX are best to use in a patient who is allergic to PCN?

What do they treat generally?

A

Monobactams

Aerobic G- spp.

18
Q

What ABX is associated with seizures?

A

Carbapenems - Imipenem

19
Q

What ABX are teamed together in synergy for folate synthesis?

A

TMP/SMX

20
Q

What 2 ABX help with uptake of Aminoglycosides?

A

PCN and Vancomycin

21
Q

S/E of tetracyclines

A

Teeth/bone abnormalities

22
Q

S/E of Polymyxins

A

Tinnitus, CNS problems.

23
Q

What is commonly teamed w/ tazobactam?

A

Piperacillin -> anti-pseudomonal PCN

Mechanisms of Disease Exam #3 (11 decks)

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