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30038 > Antimicrobial Resistance 1 > Flashcards

Antimicrobial Resistance 1 Flashcards

1
Q

Antimicrobial resistance

A

Resistance for different types of microorganisms and encompasses resistance to antibacterial, viral, parasitoc and biotic 30038 Immunity 3

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2
Q

Impact amr

A 
Global health priority  and difficulty to treat
Patient morbidity and mortality 
Increased patients stays
Complexity and duration of treatment 
Increased healthcare costs
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3
Q

Discovery of antibiotics

A

1930 and developed in 1940s
Reduced mortaloty in infectious diseases
Now there are varying degrees of bacterial resistance to all antibiotics

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4
Q

Penicillin

A

1928 by alesander fleming
Developem by florey and chain

Life expectancy has increased

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5
Q

Treatment is not forever

A

Not difficult to make microbes resistant to penicillin by exposung them to concentrations that are not sufficient to kill them

Recognised in the antibiotic era
Threatens pur ability to control infection

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6
Q

Examples of amr

A

Mrsa ( methicillin resistant staphylococcus aureus) wound infection
Mrse ( methicillin resistant staphylococcus epidermidis) wound infection
Vre (vancomycin resistant enterococcus)
Uti
Penicillin resistant streptococcus pneumonia
Penicillin resistant haemophilus influenza
Multidrug resistant mycobacterium tuberculosis

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7
Q

Various species and responsible for

A 
Klebsiella- peritonitis 
Escherichia - uti
Enterobacter - biliary tract infection 
Protues - hospital acquired pneumonias
Pseudomonas- wound infection
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8
Q

Action antibiotics

A

Bacteriostatic prevention of bacterial cell division

Bactericidal killing the bacteria

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9
Q

Types of antibiotics

A

Narrow-spectrum antibiotics

broad spectrum

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10
Q

Narrow spectrum antibiotic

A

Effective against limited range of pathogens

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11
Q

Broad spectrum antibiotics

A

Effective against a wide a range of pathogens

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12
Q

Actions of antibiotics

A 
Inhibit metabolism
Inhibit cellwall synthesis
Inhibit protein synthesis 
Interferes with DNA or RNa
Interferes with cell membrane function 
Unknown
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13
Q

Inhibit metabolism

A

Sulfonamides, sulfones

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14
Q

Inhibit cell wall synthesis

A

Beta-lactams, bacitracin, glycopeptide

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15
Q

Inhibits protein synthesis

A

Aminoglycosides, aminocycitols

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16
Q

Interferes with dna or rna synthesis

A

Quinolones

17
Q

Interferes with cell membrane

A

Polypeptides

18
Q

Unknown

A

Polyethers

30038 (18 decks)

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