Antimicrobial Chemotherapy Flashcards
describe the 3 ways which antibiotics work
inhibition of cell wall synthesis
inhibition of protein synthesis
inhibition of nucleic acid synthesis
which ones inhibit cell wall synthesis
penicillins and cephalosporins
glycopeptides
explain inhibition of cell wall synthesis
inhibits enzymes responsible got cross linkage, leading to no cell wall, autolytic enzymes kill the bacteria
give examples of penicillins
benzylpenicillin, amoxicillin, flucoxacillin MSSA, co-amoxiclav
give examples of cephalosporins
cephradine, ceftriaxone
give examples of glyocpeptides
vancomycin MRSA, for patients allergic to penicillin
which ones inhibit protein synthesis
aminoglycosides, macrolides, tetracyclines
give examples of aminoglycosides
gentamicin for gram negative, toxic
give examples of marcolides
erythromycin, clarithromycin
which ones inhibit nuclei acid synthesis
trimethoprim, UTI quinolones -ciprafloxacin not used in children due to cartilage growth
what’s used in chest infection
co-trimoxazole
how are they resistant to antibiotics
production of b lactase cleaves b lactic ring leaving the antibiotic inactive
MRSA have a mutation so the antibiotics cannot bind
how is flucoxacillin different
b lactase resistant, has a narrow spectrum
how is co-amoxiclav different
combines amoxicillin with b lactase inhibitor. the inhibitor prevents the enzyme from breaking down the amoxicillin
name types of anti-fungal drugs
polyenes, azoles,
