Antilipemic Drugs

Question 1

HMG-CoA Inhibitors

Answer 1

MOA- inhibit enzyme HMG-CoA reductase which decreases production of cholesterol

Therapeutic- Lower LDL cholesterol in blood

Adverse effects- GI disturbances, rash, headache

Drug - end with -statin

Question 2

Bile Acid Sequestrants

Answer 2

MOA- bind to bile acids and prevent reabsorption of bile acids from the small intestine

Therapeutic- reduce LDL and management of type II hyperlipoproreinemia

Adverse Effects - constipation, heartburn, nausea, belching and bloating

Drug- cholestyramine resin

Question 3

Nicotinic Acid

Answer 3

MOA- unknown, inhibits lipolysis I’m adipose tissue and increases activity of lipoprotein lipase

Therapeutic- lower lipid levels

Adverse effects- flushing, pruritis, GI distress

Question 4

Fibric Acid Derivatives

Answer 4

MOA- activate enzyme for the breakdown of cholesterol

Therapeutic- lower triglyceride levels and increase HDL

Adverse effects- abdominal discomfort, diarrhea, nausea, headache, blurred vision, increased risk for fall stones and prolonged thrombin time

Drug - gemifibrozil

Question 5

Cholesterol absorption inhibitor

Answer 5

Drug - ezetimibe

Effects enhanced with statins