Antiacids

Question 1

H2 Receptor Antagonist

Answer 1

MOA - inhibit H2 receptors of acid producing parietal cells

For treatment of GERD, PUD, erosive esophagitis, upper GI bleeding, gastric hypersecretory

Drug: end in -tidine

Question 2

Proton Pump Inhibitor

Answer 2

Transports hydrogen ions out of the parietal cells decreasing pH

Used for erosive esophagitis, GERD, short term treatment of duodenal ulcers and benign gastric ulcers, gastric hypersecretory conditions and NSAID induced ulcers

Adverse Effects- increased risk of acute kidney injury, interstitial nephritis, C-diff, wrist,hip, spine fractures, pneumonia

Drug: end in -prazole

Question 3

Antacids

Answer 3

Neutralize gastric acidity

Used for acute relief of symptoms associated with peptic ulcers, gastric enteritis,gastric hyper acidity and reflux

Adverse Effects- diarrhea, constipation, kidney stones, systemic alkalosis, hyper acidity, long term-bleeding ulcers

Drugs: aluminum, magnesium, calcium, sodium salts

Question 4

Antibiotics

Answer 4

Attaches to bacterial cell wall and outcome is death

Treatment of ulcer disease due to H-pylori

Adverse Effects- seizures, C-diff, diarrhea, rash

Drug- amoxicillin

Question 5

Sucralfate

Answer 5

Attached to surface of ulcer and detached into aluminum hydroxide

Actives stress ulceration, long term therapy for PUD, esophageal erosions

Adverse Effects: constipation

Question 6

Misoprostol

Answer 6

Block gastric acid secretion and protect mucosa from damage

Reduce gastric ulcers in those taking NSAIDs

Adverse Effects- abdominal pain, diarrhea