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Pharmacology chapter 6 > ANTIHYPERTENSIVE-Sympathoplegics > Flashcards

ANTIHYPERTENSIVE-Sympathoplegics Flashcards

1
Q

Sympatholytics
Adrenergic antagonist
Adrenergic blockers

A

Sympathoplegics

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2
Q

What are the classification of sympathoplegics

A

Centrally acting sympathoplegics

Peripherally acting

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3
Q

Site of action ni centrally acting sympathoplegics

A

Vasomotor center

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4
Q

What agonist is centrally acting sympathoplegics

A

Alpha 2 agonist

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5
Q

Drugs in centrally acting

A

Clonidine
Methyldopa
Guanfacine
Guanabenz

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6
Q

Clonidine
(Catapress)
What is the S/E

A

Rebound HTN

-secondary to clonidine withdrawal

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7
Q

What is the remedy in S/E of clonidine

A

Reinstitute clonidine
Give Beta blocker
If hypertensive crisis
– sodium nitroprusside

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8
Q

S/E of methyldopa

A

Hepatotoxicity
Can lead to hemolytic anemia
( + coombs test)

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9
Q

Pro drug

Metabolized into active form in the CNS

A

Methyldopa

Aldomet

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10
Q

Types of peripherally acting

A

Adrenergic neuronal blockers

Ganglionic blockers

Alpha blocker

Beta blocker

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11
Q

Drugs in adrenergic neuronal blocker

A

Reserpine

Guanethide, guanadrel, bretylium

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12
Q

S/E of reserpine

A

Depression

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13
Q

SE If guanethide, guanadrel

A

Orthostatic hypotension

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14
Q

It inhibit vesicular uptake of dopamine

A

Reserpine

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15
Q

Inhibut release NE

A

Guanethide guanadrel

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16
Q

Drugs in ganglionic blocker

A

Hexamethonium
Trimethaphan
Mecamyline

17
Q

Inhibit nicotinic receptor

A

Ganglionic blocker

18
Q

Types of alpha blocker

A

Non selective

Selective alpha1 blockers

19
Q

It binds to alpha1 and alpha2 blocking their action, give the drugs

A

Non selective

Phenoxybenzamine phentolamine

20
Q

What are the drugs in selective alpha 1 blocker

A

Prazosin
Terazosin
Doxazosin

21
Q

What is the SE of sel. Alpha1 blocker

A

First dose phenomenon
Orthostatic hypotension
-syncope

22
Q

Remedy for selctive alpha 1 blocker

A

Give first dose at night

Give only 1/2 dose or 1/4 dose for the first dose

23
Q

Types of beta blocker

A

Nonselective

Selective

24
Q

Drugs in nonselective beta blocker

A

Propanolol
Timolol
Pindolol
Nadolol

25
Q

Drugs in selective beta blocker

A 
Betaxolol, bisoprolol
Esmolol
Atenolol, acebutolol
Metoprolol
Celiprolol

Pharmacology chapter 6 (8 decks)

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