ANTIHYPERTENSIVE-Calcium Channel Blocker Flashcards
What is the general MOA of CCb’s
Block L-type ca channels
What are the classification of CCB’s
Based on structure & site of action
Based on duration of action
What are the types based ob structure and SOA
Dihydropyridines
Non-dihydropyridines
What are the drugs in dihydropyridine
Nifedipine
Nimodipine
Amlodipine
What are the drugs in Non dihydropyridine
Verapamil
Diltiazem
What are the SE in dihydropyridine
Peripheral edema
Reflex tachycardia
What are the SE in non dihydropyridine
Peripheral edema
Bradycardia
Verapamil
Cardioselective
Diltiazem
Cardioselective
And BV
What are the types based on duration of action
Intrinsically short acting
Intrinsically long acting
Modified long acting
What are the drugs in intrinsically short acting
All non dihydropyridine
Non-dihydropyridine except LAL
- lecarnidipine
- amlodipine
- lacidipine
☝🏻️ reflex tachycardia
Intrinsically short acting
What are the drug in intrinsically long acting
LAL
Modified long acting
Intrinsically short acting but have been made available as modified release preparation
What are the drugs in modified long acting
Felodipine (plendil ER)
Versant ( XR)
Verapamil ( SR)
Nifedipine (adalat GITS)
– gastrointestinal therapeutic/transit system
