ANTIHYPERTENSIVE-Angiotensin Antagonists

Question 1

What are the angitensin antagonist

Answer 1

ACEi

ARBs

Question 2

What are the effects of ACEi

Answer 2

Vasodilation
☝🏻️bradykinin
☝🏻️PG effect (from bradykinin effect)

Question 3

Which is more potent?

ACEi
Or
ARBs

Answer 3

ACEi

Question 4

ACEi is C/I with?

Answer 4

NSAIDs

Question 5

What are the acute ACEi?

Answer 5

Captopril
Lisinopril
Enalaprilat

Question 6

What are the prodrugs of ACEi

Answer 6

The rest of -prils

Enalapril–> enalaprilat
Perindipril–> perindoprilat

Question 7

What is the MOA of ARBs

Answer 7

Inhibit binding of angiotensin II to its receptor causing vasodilation

Question 8

What are the drugs in ARBs

Answer 8

Losartan
Candesartan
Irbesartan

Question 9

SE in ACEi

Answer 9

Idiosyncratic cough
–bec of bradykinin
Angioedema

Question 10

What are the remedy in idiosyncratic cough

Answer 10

• 👇🏻dose
• stop tx and restart at lower dose

-if intolerance and recurrent:
Shift to ARBs

Question 11

Remedy for angioedema

Answer 11

Stop right away and shift to ARBs

Question 12

SE in ARBs

Answer 12

• hyperkalemia
• interstitial nephritis
• hypotension

Question 13

First line mgngt of HTN

Answer 13

ACEi and ARBs

according to JNC 8

Question 14

First line in the …

Answer 14

HTN + CKD
HTN + DM
HTN + DM + CKD

Question 15

Whar are the drugs used in the mngt of uncomplicated HTB

Answer 15

Thiazides
Arb
Acei
CCBs