antifungals

Question 1

mechanism of amphotericin B

Answer 1

binds ergosterol and forms pores in membrane

Question 2

mechanism of azoles

Answer 2

inhibits ergosterol synthesis by inhibiting fungal p450 that converts lanosterol to ergosterol

Question 3

mechanism of flucytosine

Answer 3

inhibits DNA synthesis

used with amphotericin B

Question 4

mechanism of nystatin

Answer 4

binds ergosterol and increases permeability of cell membrane

Question 5

mechanism of Caspofungin

Answer 5

inhibits cell wall synthesis by inhibiting beta glucan

Question 6

mechanism of griseofulvin

Answer 6

disrupts mitosis by interfering with microtubule formation.

fungal-static