Antifungal Drugs: Ch. 42

Question 1

Nystatin

-Topical uses?
-Oral uses/methods?
-AEs?

Answer 1

Topical: abdominal fold yeast infections

Oral Methods:
-Troche: dissolve fully
-Swish/Swallow: as long as possible before swallowing

N/V/D, anorexia, rash

Question 2

What are the 2 system antifungal drugs?

Which is the first choice?

Answer 2

Fluconazole
-first choice
-systemic infections
-cryptococcal meningitis
-yeast infections

Amphotericin B
-severe systemic infections
-severe AEs

Question 3

Explain the AEs of Amphotericin B

Answer 3

Cardiac dysrhythmias
Neurotoxicity
Nephrotoxicity
Flu-like symptoms
Pulmonary infiltrates
Hypotention
Anemia

Question 4

Explain the prevention and mitigation of Amphotericin B AEs

Answer 4

Anticipate before treating
PADS:
Premedicate
Acetaminophen + Antiemetic
Benadryl
Steroids

Infuse slowly over 2-6 hours

Question 5

What are some AEs for Fluconazole?

Answer 5

N/V/D, abdominal pain
Increased liver enzymes

Cautionary use for pts w/ renal and/or hepatic dysfunction

Question 6

What is Diphenhydramine?

When should it be involved in antifungal use?

Answer 6

Benadryl
-antihistamine

-PADS- treatment of Amphotericin B AEs