ANTIDYSRHYTHMICS Flashcards
What is arrhythmia?
Absence of rhythm
What is dysrhythmia?
Disturbance in rhythm
How are dysrhythmias classified?
Site of origin, effect and frequency of occurrence
What are the possible sites of origin of dysrhythmias?
Atrial
Ventricular
Junctional (supraventricular)
What is meant by a true dysrhythmia?
A very disorganised rhythm
What is meant by tachycardia?
Heart beat too fast
What is meant be bradycardia?
Heart beat too slow
What is paroxysmal supraventricular tachycardia?
Happens in attacks, rapid but regular heart beat
What are ectopic heartbeats?
Skipped or extra heartbeats leading to irregular heart rate and heart rhythm
What is multifocal atrial tachycardia?
electrical impulses arriving from multiple locations within atria
What is ventricular fibrillation?
Rapid heartbeat initiated within ventricles. It is characterised by 3 or more consecutive premature ventricular beats
What is the most common type of bradydysrhythmia?
Heart block - communication between atria and ventricles is disrupted
What is the difference between first, second and third degree heart block?
First: slowed conductance through AVN
Second: some atrial impulses fail to make it through to ventricles
Third: no conduction from atria to ventricles - complete heart block
What is asystolic arrest?
Complete cessation of electrical activity - bradydysrhythmia
What are the five main mechanisms that lead to dysrhythmia?
Ectopic pacemakers - conducting tissue other than SAN initiate heart beat
Delay after depol - build up on Ca2+ in cells leading to train of APs
Re-entry circuits - Tissue damage leads to AP travelling in circles
Congenital abnormalities - additional conducting pathways between atria and ventricles
Heart block - damage to conducting pathways disrupts signalling between atria and ventricles
Ectopic foci lead to an odd shaped ___ wave on ECG
P
Heart rate increase if rate of ectopic focus exceeds rate of SAN. True or false?
True
What takes place in AF that leads to abnormal impulse generation?
Atrial myocytes contract independently, each atria potentially acts as ectopic focus so there is no coordinated contraction of atria so QRS complex occurs at irregular intervals
Ventricular fibrillation can be a result of ectopic foci or re-entry circuits. True or false?
True
Ventricular fibrillation is a true arrhythmia. True or false?
True
In ventricular fibrillation, the ventricles are not coordinated in contraction and there is no ____ wave on ECG
QRS
What is Wolff-Parkinson-White syndrome?
A congenital abnormality where there are additional conducting pathways between the atria and ventricles known as Kent bundles.
Signals go via AVN and Kent bundles leading to atrial flutter - ventricles try to keep up pace with atria - sudden death possible
Kent bundles can also set up re-entry circuits
Can Kent bundles be surgically removed?
Yes - if one or two present usually surgically removed
All dysrhytmias are abnormal and dangerous. True or false?
False - sinus dysrhythmia is an alteration of HR brought about by breathing - particularly common in young people
What is the VW system?
main classification system used for anti-dysrhythmic drugs
In the VW system, which receptors are targeted in the different classes?
Class I - Na channels Class 2 - B1 receptor Class 3 - K channel Class 4 - Calcium channel Unclassified - various
What are the main drugs in the classes of VW system?
Class I - Lidocaine
Class 2 - Atenolol
Class 3 - Amioderone
Class 4 - Verapamil