Antidiarrheals/Laxatives/Antiflatulents

Question 1

Diphenoxylate/atropine

Indications?

Dosage Forms?

Answer 1

Lomotil
* Abuse potential at high doses (C-V)
* Avoid use in patients under 6 years old
* Beers med
* Interacts with other sedating drugs (diphenhydramine, hydrocodone, etc.)
* May cause dry mouth, drowsiness, and N/V

Diarrhea

Oral solid, liquid

Question 2

Loperamide

Indications?

Dosage Forms?

Answer 2

Imodium
* Abuse potential at high doses
* Avoid use in patients under 2 years old

Diarrhea

Oral solid, liquid

Question 3

Methylcellulose

Indications?

Dosage Forms?

Answer 3

Citrucel
* Should be seperated from certain meds (digoxin, etc.)

Constipation

Oral powder (suspension), oral solid

Question 4

Psyllium

Indications?

Dosage Forms?

Answer 4

Metamucil
* Should be seperated from certain meds (digoxin, etc.)

Constipation

Oral powder (suspension), oral solid

Question 5

Docusate

Indications?

Dosage Forms?

Answer 5

Colace
* Oral liquid can be mixed with juice or milk

Constipation

Oral solid, liquid, rectal

Question 6

Lactulose

Indications?

Dosage Forms?

Answer 6

Kristalose
* Use with caution in patients with diabetes due to high sugar content

Constipation

Oral liquid, powder (suspension)

Question 7

Magnesium citrate

Indications?

Dosage Forms?

Answer 7

Citroma
* Avoid red or purple colored liquid dosage forms in patients using med as a bowel prep
* Use with caution in patients with kidney disease

Constipation, bowel prep

Oral solid, liquid

Question 8

Magnesium hydroxide

Indications?

Dosage Forms?

Answer 8

Phillps’ Milk of Magnesia
* Use with caution in patients with kidney disease

Constipation

Oral solid, liquid

Question 9

Polyethlene glycol 3350

Indications?

Dosage Forms?

Answer 9

Golytely/Miralax
* Avoid mixing bowel prep with/consuming any products containing red or purple dye

Constipation, bowel prep

Oral powder (suspension)

Question 10

Bisacodyl

Indications?

Dosage Forms?

Answer 10

Dulcolax
* Abuse potential for weight loss
* Use with caution in pregnant patients

Constipation

Oral solid, rectal

Question 11

Senna

Indications?

Dosage Forms?

Answer 11

Senokot
* Abuse potential for weight loss
* Use with caution in pregnant patients

Constipation

Oral solid, liquid

Question 12

Lubiprostone

Indications?

Dosage Forms?

Answer 12

Amitiza
* Should be taken with food

Constipation

Oral solid

Question 13

Linaclotide

Indications?

Dosage Forms?

Answer 13

Linzess
* Avoid use in patients under 2
* Should be taken on an empty stomach

Constipation

Oral solid

Question 14

Plecanatide

Indications?

Dosage Forms?

Answer 14

Trulance
* Avoid use in patients under 6

Constipation

Oral solid

Question 15

Alvimopan

Indications?

Dosage Forms?

Answer 15

Entereg
* For inpatient use only
* Can only be taken for a max of 7 days
* REMS med

Prevent bowel slowing after surgery

Oral solid

Question 16

Methylnaltrexone

Indications?

Dosage Forms?

Answer 16

Relistor
* May cause opioid withdrawal in patients who take opioids
* Should be taken on an empty stomach

Opioid-induced constipation

Oral solid, injectable

Question 17

Naldemedine

Indications?

Dosage Forms?

Answer 17

Symproic
* May cause opioid withdrawal in patients who take opioids

Opioid-induced constipation

Oral solid

Question 18

Naloxegol

Indications?

Dosage Forms?

Answer 18

Movantik
* May cause opioid withdrawal in patients who take opioids
* Should be taken on an empty stomach

Opioid-induced constipation

Oral solid

Question 19

Simethicone

Indications?

Dosage Forms?

Answer 19

Gas-X
* Often found in combo products with antacids

Gas

Oral solid, liquid