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Pharm I > Antidepressants: SSRIs > Flashcards

Antidepressants: SSRIs Flashcards

1
Q

What does SSRI stand for?

A

Selective serotonin reuptake inhibitors

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2
Q

What is the mechanism of action for SSRIs?

A

Selectively block/inhibit the reuptake of serotonin

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3
Q

What are some examples of SSRIs?

A

Fluoxetine
Sertaline
Paroxetine
Fluvoxamine

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4
Q

Can you take an SSRI with an MAOI (monamine oxidase inhibitor)? Why or why not?

A

No; SSRIs can interact adversely with MAOIs and other serotonergic drugs; these combinations must be avoided

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5
Q

What is the most common complaint with SSRIs?

A

Sexual side-effects

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6
Q

For SSRIs, who is at higher risk for suicidal ideation: Younger ages or older ages?

A

Younger ages;

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7
Q

When are people most likely to commit suicide?

A

After discharge

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8
Q

What is the chemical name for serotonin?

A

5-hydroxytryptamine (5-HT)

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9
Q

SSRIs selectively block the reuptake of serotonin, what kind of neurotransmitter is serotonin?

A

Monamine

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10
Q

Since the reuptake of serotonin is blocked, the concentration of serotonin (5-HT) in the synapse ______, causing increased activation of post-synaptic 5-HT receptors.

A

Increases

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11
Q

SSRIs block 5-HT receptors within hours of dosing, but relief of depression takes several weeks to fully develop. What is this suggesting?

A

Therapeutic effects are the result of adaptive cellular changes that take place in response to prolonged reuptake blockade

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12
Q

Do SSRIs block reuptake of dopamine or norepinephrine?

A

No

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13
Q

SSRI: Fluoxetine

Does fluoxetine block cholinergic, histaminergic, or alpha1-adrenergic receptors?

A

No

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14
Q

SSRI: Fluoxetine

Does fluoxetine produce CNS excitation or sedation?

A

Excitation

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15
Q

SSRI: Fluoxetine

Has death from overdose with fluoxetine been reported?

A

No

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16
Q

SSRI: Fluoxetine- Adverse effects

What are the most common side effects for fluoxetine?

A 
Sexual dysfunction
Nausea
Headache
Manifestations of CNS stimulation (nervousness, insomnia, and anxiety)
Weight gain
17
Q

Can SSRIs cause serotonin syndrome?

A

Yes; Begins 2-72 hours after treatment onset

18
Q

If you are taking a SSRI drug, what would increase your risk of serotonin syndrome?

A

Concurrent use of MAOIs and other drugs

19
Q

Of the SSRIs, which one (fluoxetine, sertraline, paroxetine, or fluvoxamine) is the least likely to cause a withdrawal reaction?

A

Fluoxetine

20
Q

SSRIs: Use of fluoxetine and other SSRIs LATE in pregnancy poses a small risk for what 2 effects in the newborn?

A
  • Neonatal abstinence syndrome (NAS)

- Persistent pulmonary hypertension of the newborn (PPHN)

21
Q

Do fluoxetine and other SSRIs cause birth defects?

A

Probably not; and if they do, the risk is very low

22
Q

What two SSRIs may cause septal heart defects in a newborn? Is this risk high or low?

A

Paroxetine and fluoxetine

Very low

23
Q

SSRI: Sertraline
Sertraline blocks the reuptake of _____.
Sertaline relieves ______.
Sertaline causes CNS stimulation or sedation?

A

Sertraline blocks the reuptake of serotonin.
Sertraline relives symptoms of major depression.
Sertaline causes CNS stumulation

24
Q

SSRI: Can sertraline be combined with MAOIs?

A

No

25
Q

If you are on sertraline, and you need to start taking an MAOI, how long must the prescriber wait to start the MAOI after finishing the sertraline?

A

14 days

26
Q

If you are taking an MAOI, and you need to start taking a sertraline, how long must the prescribe wait to start sertraline after finishing the MAOI?

A

14 days

27
Q

SSRI: Paroxetine

What is this drugs mechanism of action?

A

Blocking the reuptake of seratonin

28
Q

SSRI: Paroxetine

What pregnancy risk category is this drug and why?

A

D

Because of the small risk that the baby will of cardiovascular birth defects (primary ventricular septal defects)

29
Q

SSRI: Fluvoxamine

Does this SSRI cause CNS stimulation or sedation?

A

Moderate sedative effects

30
Q

All the SSRI drugs poses risks for what 4 things

A

HYPOnatremia
GI bleeding
NAS (neonatal abstinence syndrome)
PPHN (persistent pulmonary hypertension of the newborn)

31
Q

ALL the SSRI drugs CANNOT be taken with what other antidepressant?

A

MAOIs

32
Q

Which 3 of the 4 SSRIs cause CNS stimulation?

A

Fluoxetine
Sertraline
Paroxetine

33
Q

Which of the SSRIs causes moderate CNS sedative effects?

A

Fluvoxamine

Pharm I (30 decks)

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