Antidepressants: MAOIs Flashcards
What does MAOI stand for?
Monoamine oxidase inhibitors
Out of TCA, SSRI, and MAOI, what is the most hazardous class of drugs?
MAOI
What is the greatest concern for why MAOIs are hazardous?
They can cause a hypertensive crisis
How is a MAOI hypertensive crisis triggered by?
Eating foods rich in tyramine
What is the mechanism of action of MAOIs?
Prevent the destruction of ALL monamines, causing levels to rise
What monamines do MAOIs effect?
ALL OF THEM: serotonin, dopamine, norepinephrine
What are some examples of MAOIs?
Isocarboxazied
Phenelzine
Tranylcypromine
Selegiline
Out of TCAs, SSRIs, and MAOIs, which is the best at relieving depression?
They are all equal in relieving depression
Since TCAs, SSRIs, and MAOIs are all equal in relieving depression, why are MAOIs one of the last choices and who usually gets prescribed MAOI drugs?
They are second or third choice antidepressants for most patients because they are so hazardous. The ones who are prescribed MAOIs are those who have not responded already to a SSRIs, TCAs, and other safer drugs
Is there any instance in which MAOIs are the first choice of anti-depressants? If so, for who?
Yes; those with atypical depression
Do MAOIs cause CNS stimulation or sedation?
Stimulation
MAOIs effects usually produce what effect: hypotension or hypertension
Usually hypotension since MAOIs reduce blood pressure, but they can be the cause of severe hypertension if they eat foods that are rich in tyramine
Can you prescribe a patient both an MAOI and SSRI?
No; increased risk for serotonin syndrome
Can you prescribe a patient both a TCA and MAOI?
No; produces hypertensive episodes or hypertensive crisis
Can you prescribe a patient both a MAOI and meperidine (demerol)
No; can cause hyperpyrexia (excessive elevation in temp)
