Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PCOL 2 > anticoagulants > Flashcards

anticoagulants Flashcards

1
Q

Heparin (Chemistry)

A

Sulfated glycosaminoglycan

a. unfractionated
b. low –MW

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Warfarin (Chemistry)

A

Coumarin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Heparin (ROA)

A

Parenteral (IV or SC)

Not IM - produce hematoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Warfarin (ROA)

A

Oral, IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Heparin (Uses)

A

Post MI
Prevention of DVT and PE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Warfarin (Uses)

A

Prevention of DVT and PE
Atrial fibrillation
Atificial heart valves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Heparin (Mechanism)

A

Activates antithrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Warfarin (Mechanism)

A

Inhibits Vit. K synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Heparin (Target)

A

1.5 - 2.5x control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Warfarin (Target)

A

INR 2-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Heparin Side Effects

A

Bleeding
Allergy
Thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Warfarin Side Effects

A

Bleeding
Teratogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Heparin Monitoring

A

Activated partial thromboplastin time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Warfarin Monitoring

A

Prothrombin time (expressed as INR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Heparin Antidote

A

Protamine sulfate (1mg/100 units)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Warfarin Antidote

A

Vitamin K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Unfractionated heparin MW

A

5,000-30,000 Daltons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Low molecular weight heparins (LMWH)

A

Enoxaparin
Dalteparin
Tinzaparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q
  • Longer half life
  • Less bleeding, routine aPTT unnecessary
A

Low Molecular Weight Heparins (LWMH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Mixture of sulfated glycosaminoglycosan
(heparin, dermatan, chondroitin)

A

Danaparoid Na

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Danaparoid Na is a mixture of sulfated glycosaminoglycosan:

A

Heparin
Dermatan
Chondroitin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Note: Heparin is a preferred drug given to a pregnant woman, It does not cross the placenta.

23
Q

Heparin and Related Agents

A
  • Unfractionated Heparin
  • Low Molecular Weight Heparins
  • Danaparoid Na
  • Fondaparinux Na
24
Q

Coumarin Derivatives

A
  • Warfarin sodium
  • Dicumarol
25
Q

It dissolves clot

  • converts plasminogen—-plasmin (fibrinolytic)
A

Thrombolytics (Enzymes)

26
Q

Types of Thrombolytics

A
  • Streptokinase
  • Tissue Plasminogen Activators
27
Q

It is a protein from streptococci

A

Streptokinase

28
Q

Uses of Streptokinase

A
  • MI, DLVT (deep venous thrombosis) , PE (pulmonary embolism)
29
Q

Side Effects of Streptokinase

A

Hemorrhage
Allergy

30
Q

Examples of Tissue Plasminogen Activators

A

Alteplase
Reteplase
Streptokinase

31
Q

Uses of TPA

A
  • MI, DLVT, PE
32
Q

It only binds to plasminogen bound to fibrin

A

Tissue Plasminogen Activators

33
Q

Side Effect of TPA

A

Hemorrhage

34
Q

It inhibits platelet aggregation and prolongs bleeding time

A

Antiplatelets

35
Q

Uses of Antiplatelets

A

Prevention of MI, Stroke

36
Q

It prevents thromboxane synthesis by inhibiting cyclooxygenase

37
Q

Uses of Aspirin

A

Prevention of MI, Stroke

38
Q

Side Effects of Aspirin

A

GI Ulcer
Bleeding

39
Q

It blocks ADP(adenosine diphosphate) receptor in the platelet cell membrane

A

Thienopyridines

40
Q

Uses of Thienopyridines

A

Prevention of MI, Stroke

41
Q

Side Effects of Clopidogrel

A

Nausea
Vomiting
Diarrhea
Hemorrhage

42
Q

Side Effects of Ticlopidine

A

Neutropenia

43
Q

It inhibits adenosine reuptake—-decrease platelet aggregation

It inhibits phosphodiesterase—–Inc. cGMP—vasodilation

A

Dipyridamole

44
Q

It is for patients undergoing percutaneous coronary intervention (angioplasty)

A

Glycoprotein IIb/ IIIa inhibitors

45
Q

Examples of Glycoprotein IIb/ IIIa inhibitors

A

Abciximab
Eptifibatide
Tirofiban

46
Q

Side Effects of Glycoprotein Inhibitors

47
Q

Glycoprotein IIB/IIA Inhibitors Use

A

To decrease the incidence of hemorrhage

48
Q

Vitamin K and its synthetic derivatives

A

Vitamin K1 (phytonadione) - fat soluble
Vitamin k3 (menadione) - fat soluble
Vitamin K4 (menadiol) -water soluble

49
Q

Vitamin K MOA

A

Promotes the synthesis of Factors II, VII ,IX and XI

50
Q

Factor II

A

Prothrombin

51
Q

Factor VII

A

Proconvertin

52
Q

Factor IX

A

Plasma Thromboplastin Component

53
Q

Factor XI

A

Stuart Factor

54
Q

It is the drug of choice for the treatment of anticoagulant overdose and HDN (hemorrhagic disease of newborn) because it has the same degree of activity with the naturally occurring vitamin and have better margin of safety.

A

Vitamin K1 (Phytonadione)

PCOL 2 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions