anticholinergic drugs

Question 1

Atropine

Answer 1

class: antimuscarinic/ antidote for mushroom poisoning
MOA: competitive blockade of muscarinic receptors, prevents receptor activation
therapeutic uses: decreases secretions, decreases GI motility, relaxes bronchi

Question 2

Physostigmine

Answer 2

class: antidote for atropine/ muscarinic antagonists
inhibits the enzyme that breaks down ACh therefore more ACh floats around

Question 3

Oxybutynin (Ditropan)

Answer 3

pharm class: anticholinergic
MOA: competitive blockade of muscarinic receptors on the bladder, prevents receptor activation
decreases secretions, decreases GI motility, increases HR, mydriasis

Question 4

Nicotine

Answer 4

pharm class: nicotonic agonists
in low doses activates the receptors
tx: stop smoking
in high doses can block the receptors
insecticides
tobacco poisoning - ingestion in children
tx: Atropine

Question 5

Succinylcholine (Acectine)

Answer 5

pharm class: deoplarizing neuromuscular blocker
MOA: binds to Nm receptors > depolarization > contraction and then it stays bound and prevents the end plate from repolarizing > relaxation
causes contraction then flaccid paralysis
can cause muscle pain and stiffness
monitor the potassium levels can result in dysrhythmias