Antibodies & Antigens (Exam 1) Flashcards
Antibody molecules are a ___ shape with ______ and _____ chains.
Y
heavy & light
Term for “feet” of antibody molecule.
Fc region
Term for “arms” of antibody molecule which binds antigen.
Fab region
Which regions of an antibody differ between isotypes?
hypervariable regions
List the 5 antibody types.
- IgA
- IgD
- IgE
- IgG
- IgM
Which antibodies have subtypes? How many?
IgA - IgA1 & 2
IgG - IgG1-4
Order of antibody secretion and concentration in serum from greatest to least.
IgG
IgA
IgM
IgE
IgD
Function of IgA
mucosal immunity (secreted across epithelial barriers)
Which two antibodies function as naive B cell antigen receptors?
IgD
IgM
In addition to being a naive B cell antigen receptor, IgM functions in _________.
complement activation
Of the secreted antibodies, match each to the form(s) it is secreted as:
- IgA
- IgE
- IgG
- IgM
- dimer
- monomer
- monomer
- pentamer or hexamer
Which antibody binds antigen very well and has 10 binding sites?
IgM
List the functions of IgE
- helminthic parasite defense
- allergy
- immediate hypersensitivity response
List the functions of IgG
- opsonization
- complement activation
- antibody-dependent cell-mediated cytotoxicity
Which antibody has the highest half-life and highest concentration in serum?
IgG
What are the two different forms of antibodies found?
membrane/surface-bound
secreted
(T/F) B cells need to recognize a specific epitope or antigenic determinant’s conformation on a microbe in order to response.
True
What are the 3 types of epitopes?
- conformational
- linear
- neoantigenic
What is a neoantigenic epitope is a new epitope made by degradation of a microbe via __________.
proteolysis
Term for this process:
Over time with humoral immunity, antibody regions on B cell receptors will have higher affinity for antigen and outcompete other B cells.
affinity maturation
Term for antibody changing antibody isotype overtime depending on what the immune system or cell needs.
isotype swtiching
(T/F) With isotype switching, an antibody will recognize a new antigen but will have the same effector function.
False - recognizes same antigen with new effector function
