Antibodies & Antigens (Exam 1)

Question 1

Antibody molecules are a ___ shape with ______ and _____ chains.

Answer 1

Y
heavy & light

Question 2

Term for “feet” of antibody molecule.

Answer 2

Fc region

Question 3

Term for “arms” of antibody molecule which binds antigen.

Answer 3

Fab region

Question 4

Which regions of an antibody differ between isotypes?

Answer 4

hypervariable regions

Question 5

List the 5 antibody types.

Answer 5

1. IgA
2. IgD
3. IgE
4. IgG
5. IgM

Question 6

Which antibodies have subtypes? How many?

Answer 6

IgA - IgA1 & 2
IgG - IgG1-4

Question 7

Order of antibody secretion and concentration in serum from greatest to least.

Answer 7

IgG
IgA
IgM
IgE
IgD

Question 8

Function of IgA

Answer 8

mucosal immunity (secreted across epithelial barriers)

Question 9

Which two antibodies function as naive B cell antigen receptors?

Answer 9

IgD
IgM

Question 10

In addition to being a naive B cell antigen receptor, IgM functions in _________.

Answer 10

complement activation

Question 11

Of the secreted antibodies, match each to the form(s) it is secreted as:

1. IgA
2. IgE
3. IgG
4. IgM

Answer 11

1. dimer
2. monomer
3. monomer
4. pentamer or hexamer

Question 12

Which antibody binds antigen very well and has 10 binding sites?

Answer 12

IgM

Question 13

List the functions of IgE

Answer 13

1. helminthic parasite defense
2. allergy
3. immediate hypersensitivity response

Question 14

List the functions of IgG

Answer 14

1. opsonization
2. complement activation
3. antibody-dependent cell-mediated cytotoxicity

Question 15

Which antibody has the highest half-life and highest concentration in serum?

Answer 15

IgG

Question 16

What are the two different forms of antibodies found?

Answer 16

membrane/surface-bound
secreted

Question 17

(T/F) B cells need to recognize a specific epitope or antigenic determinant’s conformation on a microbe in order to response.

Answer 17

True

Question 18

What are the 3 types of epitopes?

Answer 18

1. conformational
2. linear
3. neoantigenic

Question 19

What is a neoantigenic epitope is a new epitope made by degradation of a microbe via __________.

Answer 19

proteolysis

Question 20

Term for this process:
Over time with humoral immunity, antibody regions on B cell receptors will have higher affinity for antigen and outcompete other B cells.

Answer 20

affinity maturation

Question 21

Term for antibody changing antibody isotype overtime depending on what the immune system or cell needs.

Answer 21

isotype swtiching

Question 22

(T/F) With isotype switching, an antibody will recognize a new antigen but will have the same effector function.

Answer 22

False - recognizes same antigen with new effector function